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A gene on chromosome 19p13.3 that encodes a ubiquitously expressed serine/threonine-protein kinase which controls the activity of AMP-activated protein kinase (AMPK) family members, playing a role in various cellular processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. STK11 acts by phosphorylating the T-loop of AMPK family proteins, upregulating their activity.

Molecular pathology
Defects in STK11 are a cause of Peutz-Jeghers syndrome; it has been linked to testicular germ cell tumours and sporadically to non-small cell carcinomas of the lung. Defects in STK11 also promote carcinogenesis, including lung cancer progression and metastasis, and confers in lung adenocarcinoma the ability to trans-differentiate into squamous cell carcinoma.


Abbreviation for Peutz-Jeghers syndrome.
References in periodicals archive ?
It would great if they also included quotes or words from the enlisted pjs and not just the officers
The thought is if you get there earlier then maybe you will give the PJs that extra second to go rescue someone.
Under the current HOME Program rules, PJs cannot charge monitoring fees to owners.
Despite repeated calls to PJs the Chronicle was unable to make contact with anyone from the hotel.
John became attracted to the PJs' life and in the early 1980s he left Wales for the USA to join the USAF and the PJs.
PJS set up shop in Menomenee Falls, WI in the mid 70's by Peter Smith, president, and his brother Patrick, senior vice president, and Jim Haggith, vice president and secretary, then moved to Brookfield (greater Milwaukee area) in the mid 80's, where the company now operates.
delivering PJs finest press releases to hungry newshounds and researchers, twenty four seven.
There's a fantastic range of pjs on offer, from satin and silky smoothies, to warm fleecy pyjamas and softly brushed cotton numbers.
Afin de tirer profit du succes du PJS, un nouveau projet pilote destine au secteur prive a ete annonce dans le cadre du Forum pour l'engagement des citoyens du Nord de l'Ontario de 2002.
In other words, baggy, comfy PJs were verboten by order of the Feds.
Although the polyps may be present in childhood, PJS symptoms often do not develop for years.