PJS


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STK11

A gene on chromosome 19p13.3 that encodes a ubiquitously expressed serine/threonine-protein kinase which controls the activity of AMP-activated protein kinase (AMPK) family members, playing a role in various cellular processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. STK11 acts by phosphorylating the T-loop of AMPK family proteins, upregulating their activity.

Molecular pathology
Defects in STK11 are a cause of Peutz-Jeghers syndrome; it has been linked to testicular germ cell tumours and sporadically to non-small cell carcinomas of the lung. Defects in STK11 also promote carcinogenesis, including lung cancer progression and metastasis, and confers in lung adenocarcinoma the ability to trans-differentiate into squamous cell carcinoma.

PJS

Abbreviation for Peutz-Jeghers syndrome.
References in periodicals archive ?
They've maintained nearly perfect Pave Hawk mission readiness ratings, giving the PJs the wings with which they have saved more than 20 lives and transported more than 100 patients to medical centers this year.
The proposed rule encourages PJs to adopt one of two definitions--the Section 8 or the IRS definition.
Despite repeated calls to PJs the Chronicle was unable to make contact with anyone from the hotel.
Through the PJs he was introduced to the big mountains of Alaska," said Mr Lloyd.
PepsiCo is to ditch its PJ Smoothies brand early next year, The Grocer can exclusively reveal.
The site represents phase one of the new online presence of PJs, with more features to be introduced in the near future.
95), a cheeky take on the classic Burberry tan-coloured check with dogs; Lucy In The Chocolate Factory pjs (pounds 59.
We opted for its "blue snowflake" pattern boy's PJs ($40), as well as a girl's ($44) and woman's ($56) nightgown.
Most people with PJS have small, flat, harmless dark brown or black spots on the lips and inner cheeks.
The PJs has all the stereotypical minority characters you can put in one show, and they cavort in ways that harken back to Amos `n' Andy.
The bill eliminates the bias against new construction which will allow PJs to tailor HOME funds to meet local needs.