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A gene on chromosome 19p13.3 that encodes a ubiquitously expressed serine/threonine-protein kinase which controls the activity of AMP-activated protein kinase (AMPK) family members, playing a role in various cellular processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. STK11 acts by phosphorylating the T-loop of AMPK family proteins, upregulating their activity.

Molecular pathology
Defects in STK11 are a cause of Peutz-Jeghers syndrome; it has been linked to testicular germ cell tumours and sporadically to non-small cell carcinomas of the lung. Defects in STK11 also promote carcinogenesis, including lung cancer progression and metastasis, and confers in lung adenocarcinoma the ability to trans-differentiate into squamous cell carcinoma.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.


Abbreviation for Peutz-Jeghers syndrome.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
References in periodicals archive ?
The PJS stressed that this assault won't affect the agenda of IFJ meeting and international conference, as well, it won't obstruct journalists of doing their duties no matter the price is.
The cause of PJS is a mutant gene named STK1, also known as LKB1.
Histology verified the diagnosis of PJS. All 4 polyps showed findings suggestive of hamartomas (Figure 4).
Peutz-Jeghers syndrome (PJS), inherited as an autosomal dominant trait, is characterized by multiple gastrointestinal hamartomatous polyps, mucocutaneous pigmentation, and an increased risk of neoplasm (1,2).
PJS is inherited, autosomal dominant disorder with an incidence from 1:25,000 to 1:280,000.[sup][1] The accuracy of diagnosis is determined by the presence of histopathologically confirmed hamartomatous polyps and two following clinical criteria: family history, hyperpigmentation, and polyps in the small bowel.[sup][2] PJS polyps occur anywhere in the gastrointestinal tract except the esophagus.
London's High Court said that PJS and NGN had agreed a final order in the action for breach of confidence and misuse of private information.
But PJS successfully appealed and that was the position until earlier this week.
The PJS, Asia's oldest scientific journal which is under the DOST's Science and Technology Information Institute, publishes research studies for free, she said.
Could never leave the house in pjs but that's just me.
Chantelle Moloney: When my kids are PJ Day at school they were absolutely mortified at the idea of walking five minutes to the school in PJs. At the time she was twoyear-old.
The reader also endures the tragic effects, the chaos, the confusion, and, ultimately, the heroic efforts of the young PJs and other U.S.
"I think his trip back to Kenya is going to create a lot of chatter and commentary amongst some of the hard right, who still don't see him as having been born in the U.S.," said PJS, adding: "I personally think he's just inciting some chatter on an issue that should have been a dead issue a long time ago."