CDK9

(redirected from PITALRE)

CDK9

A gene on chromosome 9q34.1 that encodes a cyclin-dependent kinase, which regulates cell cycle progression. CDK9 is part of the multiprotein complex TAK/P-TEFb, an elongation factor for RNA polymerase II-directed transcription, which acts by phosphorylating the C-terminal domain of a subunit of RNA polymerase II. 

Molecular pathology
HIV-1 Tat protein interacts with CDK9 and cyclin T, suggesting CDK9 may have a role in AIDS.
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Chromosomal mapping of members of the cdc2 family of protein kinases, cdk3, cdk6, PISSLRE, and PITALRE, and a cdk inhibitor, p27Kip1, to regions involved in human cancer.