PINX1

PINX1

A gene on chromosome 8p23 that encodes a protein which inhibits telomerase activity; it may inhibit cell proliferation and act as tumour suppressor.
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Gene Network node IL-6 30 ETS2 29 TNF 25 OPN1MW 21 IFNAL 19 STAT1 18 SMAD1 18 EGR1 18 JUNb 17 IL-1b 16 STAT3 14 NF-kappa B 14 STAT2 13 JUN 13 FOS 13 TP53 12 TNF[alpha] 12 PTX3 12 PTGS2 12 PPARD 12 KYNU 12 IRF6 12 IL-8 12 CXCL16 12 CLEC4E 12 ATF3 12 STAT4 11 SNAI2 11 SNAIL 11 SMAD3 11 SLC2A1 11 RELA 11 REC8 11 PINX1 11 NOL3 11 MCM2 11 ILDHA 11 IGFBP3 11 GADD45G 11 G6PD 11 SP3 10 SMAD2 10 RELB 10 IL-5 10 Table 5: GO function annotation of differentially expressed genes.
PIN2/TERF1-interacting telomerase inhibitor 1 (PinX1) is a nucleolar protein evolutionarily conserved from yeasts to humans and is known to function as a suppressor of telomerase enzymatic activity through C-terminal domain binding with telomerase reverse transcriptase (TERT) [15].
PinX1 expression status has been shown to be altered in many cancers.
The evaluation of PinX1 staining was performed in a blinded, independent manner by two pathologists.
The relationship between PinX1 protein expression and clinicopathological data in patients with NSCLC was estimated using chi-squared tests.
Association between PinX1 Expression and Clinicopathological Features in Patients with NSCLC.
Association between PinX1 Protein Expression and Survival in Patients with NSCLC.
Univariate Cox regression analysis showed that sex, smoking status, lymph gland status, subcarinal lymph node status, pathological stage, and PinX1 expression were related to survival (Table 2).
PinX1 Overexpression Inhibited the Proliferation and Migration of NSCLC Cells.
H520 cells showed reduced proliferation when PinX1 was overexpressed beginning on day 3, whereas A549 cells showed reduced cell proliferation when PinX1 was overexpressed beginning on day 4 (Figure 4).
In wound healing assays, both A549 and H520 cells showed reduced cell migration when PinX1 was overexpressed compared with that in control cells at 48 h (Figure 5(a)).
The genes found outside of the KWE region that showed CNV included MSRA, RP1L1, PINX1 and XKR6.