PIN1


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PIN1

A gene on chromosome 19p13 that encodes an essential peptidylprolyl isomerase, which regulates mitosis by interacting with NIMA and downregulating its mitosis-promoting activity. PIN1 downregulates BTK’s kinase activity, transactivates multiple oncogenes and induces centrosome amplification, chromosome instability and cell transformation. PIN1 is required for efficient dephosphorylation and recycling of RAF1 after mitogen activation.
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References in periodicals archive ?
The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response.
The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults.
Boosting Pin1 levels may help untangle tau in people at risk of Alzheimer's disease, slowing the disease's progression or preventing it altogether.
While studying preserved brain tissue from people who had Alzheimer's disease, Lu and his colleagues also found that regions with the highest concentrations of Pin1 had the lowest percentages of nerve cells with tangles.
The animal and human data together create a "strong case" that Pin1 protects against Alzheimer's disease, says D.