PIN1


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PIN1

A gene on chromosome 19p13 that encodes an essential peptidylprolyl isomerase, which regulates mitosis by interacting with NIMA and downregulating its mitosis-promoting activity. PIN1 downregulates BTK’s kinase activity, transactivates multiple oncogenes and induces centrosome amplification, chromosome instability and cell transformation. PIN1 is required for efficient dephosphorylation and recycling of RAF1 after mitogen activation.
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References in periodicals archive ?
The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response.
The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults.
Boosting Pin1 levels may help untangle tau in people at risk of Alzheimer's disease, slowing the disease's progression or preventing it altogether.
While studying preserved brain tissue from people who had Alzheimer's disease, Lu and his colleagues also found that regions with the highest concentrations of Pin1 had the lowest percentages of nerve cells with tangles.
The animal and human data together create a "strong case" that Pin1 protects against Alzheimer's disease, says D.
The Pin1 enzyme, which has been linked to numerous human cancers, including prostate and breast cancer, may be one of the most prevalent tumor markers found to date.
It also means that the amount of Pin1 present in pre-therapy biopsies may allow doctors to counsel patients diagnosed with potential prostate cancer to wait and see, thereby avoiding or at least delaying surgery or radiation therapy.
According to the company, the patent effectively ensures that Pintex retains control over any clinically relevant use of a Pin1 antibody, including the development of diagnostic tests and therapies relating to Pin1.
This Pin1 patent application complements our existing comprehensive intellectual property assets, which form the basis for a potentially wide array of new cancer therapies and diagnostics," said Pintex CEO George C.
Hillman said, "The discovery of the role of the Pin1 enzyme in human cancer creates a novel target with significant potential for creating new cancer therapeutics and reducing human suffering.
These funds will be used to continue preclinical development of Pin1 inhibitors and will move the company towards partnerships with pharmaceutical companies focused on oncology.