PIK3R2

PIK3R2

A gene on chromosome 19q13.2-q13.4 that encodes a regulatory subunit of phosphoinositide 3-kinase. PIK3R2 binds to activated (phosphorylated) protein-Tyr kinases through its SH2 domain and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane.
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Additionally, miR-126 could enhance EPC homing to thrombogenic and ischemic area by targeting PIK3R2 and CXCR4, which plays an important role in the therapeutic effect of EPCs on ischemic diseases [39, 49, 50].
Yu et al., "Upregulation of MicroRNA126 contributes to endothelial progenitor cell function in deep vein thrombosis via its target PIK3R2," Journal of Cellular Biochemistry, vol.
demonstrated that miR-126 targeting PIK3R2 can promote growth and apoptosis of RASF by regulating the PI3k/AKT signaling pathway, which was presented as a therapeutic strategy [63].
Zhao, "microRNA-126 targeting PIK3R2 promotes rheumatoid arthritis synovial fibro-blasts proliferation and resistance to apoptosis by regulating PI3K/AKT pathway," Experimental and Molecular Pathology, vol.
Xie et al., "Endothelial-specific intron-derived miR-126 is down-regulated in human breast cancer and targets both VEGFA and PIK3R2," Molecular and Cellular Biochemistry, vol.
High frequency of PIK3R1 and PIK3R2 mutations in endometrial cancer elucidates a novel mechanism for regulation of PTEN protein stability.
The PIK3R2 has also been established as a novel cancer gene.
Cheung et al., "High frequency of PIK3R1 and PIK3R2 mutations in endometrial cancer elucidates a novel mechanism for regulation of PTEN protein stability," Cancer Discovery, vol.
Stored for various periods Skin Fresh punch Mx-A, SOD1, WARS, [107] biopsies from PIK3r2, proteasomal the forearm of PA28-[alpha] and SSP 21-30 and 75- 0107 92 years old donors WI-38 human Decrease activity of [39] embryonic proteasomal CT-L, fibroblasts.
miR-126 is recognized as the most important miRNA for maintaining vascular integrity during ongoing angiogenesis, as it targets SPRED1 and PIK3R2, two negative regulators of VEGFs signaling [35].
Mutations in three genes, AKT3, PIK3R2 and PIK3CA, were also found to be associated with a constellation of disorders including cancer, hydrocephalus, epilepsy, autism, vascular anomalies and skin growth disorders.
AKT3, PIK3R2 and PIK3CA are present in all humans, but mutations in the genes are what lead to conditions including megalencephaly, cancer and other disorders.