10097090 TAFIA CD3EAP 15226435 GHR PIK3R1
9632636 MAPK8 PIK3R1
7642542 PTK2B PIK3R1
10797305 SLC2A4 CTSD 16396496 CRKL PIK3R1
9461587 With these two nodes provided, their edge is implied.
(24) The most common genetic mutations in type I cancers include PTEN, PIK3R1
, and PIK3CA mutations.
AKT1 DICER1 FOXL2 POLE BRAF ERBB2 KRAS PTEN CDKN2A FBXW7 PIK3CA RB1 CTNNB1 FGFR2 PIK3R1
Similar to the previous pathways discussed above, GNAS was the only up-regulated gene (expression value 0.573); while the other genes associated with these pathways are down-regulated (ATM, CAMK4, FNBPI, ITPR1, NAPEPLD, PIK3R1
, PRKA, PRKCH, and RHOH).
(4) performance of gene set consisting of DNAJB5, RAC3, SLA2, HDLBP, PRG2, PER1, PIK3R1
, and EAPP to dinstinguish between high and low [PM.sub.10] exposure in men (above 75th percentile corresponding to 24.5 [micro]g/[m.sup.3]) and low (< 24.5 [micro]g/[m.sup.3]) and (B) performance of gene set consisting of ARHGAP4, AKAP6, PYGO2, HTR1B, ATG16L2, SIRT7, TPM3 and LIMK1 in women to distinguish between high (above 75th percentile corresponding to: 25.7 Mg/m3) and low (< 25.7 Mg/m3) long-term residential [PM.sub.10] exposure.
MicroRNA-486-5p, which is downregulated in hepatocellular carcinoma, suppresses tumor growth by targeting PIK3R1
. FEBS J 2015; 282: 579-594, doi: 10.1111/ febs.13167.
Functional analysis revealed that the biomarker is enriched for genes involved in cell proliferation (IFIT3, PML, PTPN6, PTPRU, TBRG1, WNK2, and ZEB1) and in cytokine signaling (DDX58, IFIT3, PIK3R1
, PIK3R5, PML, PTPN6, and SKP1), supporting previous evidence of cell- and interferon-mediated immune responses to be linked to humoral responses to influenza vaccination.
[up arrow] PIK3R1
 miR-16-5p [down arrow] MTOR, RPS6KB1 Lee et al.
Frange et al., "A human immunodeficiency caused by mutations in the PIK3R1
gene," The Journal of Clinical Investigation, vol.
In general, EC has alterations on PI3KCA, PIK3R1
, AKT1, and PTEN in about 59.7%, 33%, 3.2%, and 66% of cases, respectively.
Another interesting gene was PIK3R1
, whose methylation was higher in Asians than in Whites (P = 0.01; FC = 2.33).
Heterozygous splice mutation in PIK3R1
causes human immunodeficiency with lymphoproliferation due to dominant activation of PI3K.