PIK3R1

PIK3R1

A gene on chromosome 5q13.1 that encodes a regulatory subunit of phosphoinositide 3-kinase. PIK3R1 binds to activated (phosphorylated) protein-Tyr kinases through its SH2 domain and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. It is necessary for the insulin-driven increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues, and it plays an important role in signalling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. PIK3R1 also plays a role in ITGB2 signalling.
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INPP4A PIK3R1 10097090 TAFIA CD3EAP 15226435 GHR PIK3R1 9632636 MAPK8 PIK3R1 7642542 PTK2B PIK3R1 10797305 SLC2A4 CTSD 16396496 CRKL PIK3R1 9461587 With these two nodes provided, their edge is implied.
(24) The most common genetic mutations in type I cancers include PTEN, PIK3R1, and PIK3CA mutations.
AKT1 DICER1 FOXL2 POLE BRAF ERBB2 KRAS PTEN CDKN2A FBXW7 PIK3CA RB1 CTNNB1 FGFR2 PIK3R1 TP53
Similar to the previous pathways discussed above, GNAS was the only up-regulated gene (expression value 0.573); while the other genes associated with these pathways are down-regulated (ATM, CAMK4, FNBPI, ITPR1, NAPEPLD, PIK3R1, PRKA, PRKCH, and RHOH).
(4) performance of gene set consisting of DNAJB5, RAC3, SLA2, HDLBP, PRG2, PER1, PIK3R1, and EAPP to dinstinguish between high and low [PM.sub.10] exposure in men (above 75th percentile corresponding to 24.5 [micro]g/[m.sup.3]) and low (< 24.5 [micro]g/[m.sup.3]) and (B) performance of gene set consisting of ARHGAP4, AKAP6, PYGO2, HTR1B, ATG16L2, SIRT7, TPM3 and LIMK1 in women to distinguish between high (above 75th percentile corresponding to: 25.7 Mg/m3) and low (< 25.7 Mg/m3) long-term residential [PM.sub.10] exposure.
MicroRNA-486-5p, which is downregulated in hepatocellular carcinoma, suppresses tumor growth by targeting PIK3R1. FEBS J 2015; 282: 579-594, doi: 10.1111/ febs.13167.
Functional analysis revealed that the biomarker is enriched for genes involved in cell proliferation (IFIT3, PML, PTPN6, PTPRU, TBRG1, WNK2, and ZEB1) and in cytokine signaling (DDX58, IFIT3, PIK3R1, PIK3R5, PML, PTPN6, and SKP1), supporting previous evidence of cell- and interferon-mediated immune responses to be linked to humoral responses to influenza vaccination.
[up arrow] PIK3R1 [101] miR-16-5p [down arrow] MTOR, RPS6KB1 Lee et al.
Frange et al., "A human immunodeficiency caused by mutations in the PIK3R1 gene," The Journal of Clinical Investigation, vol.
In general, EC has alterations on PI3KCA, PIK3R1, AKT1, and PTEN in about 59.7%, 33%, 3.2%, and 66% of cases, respectively.
Another interesting gene was PIK3R1, whose methylation was higher in Asians than in Whites (P = 0.01; FC = 2.33).
Heterozygous splice mutation in PIK3R1 causes human immunodeficiency with lymphoproliferation due to dominant activation of PI3K.