PIK3CG


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PIK3CG

A gene on chromosome 7q22.3 that encodes the gamma catalytic subunit of phosphoinositide-3-kinase (PI3K), which phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol-3,4,5-triphosphate (PIP3). This gamma catalytic subunit forms a heterodimer with PIK3R5 or PIK3R6 regulatory subunits; its interaction with ADRBK1 through the PIK helical domain is required for targeting to agonist-occupied receptor. It is thought to interact with PDE3B, TPM2 and EPHA8, and to regulate integrin-mediated cell adhesion to substrates.
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Genes of diverse functional groups and signaling routes appeared: Cytoskleleton (BCL7A, DYNC1L12, SEFT10, SEPT11), transcriptional and translational regulation (DEPDC1, GABPB1, LHFPL2, NFIB, POLR3C, RPL34, RPS3A, RPS21, RPS25, TFDP2, TRIM24, ZBTB1, ZBTB38, ZFP112), cell death (CASP2, INC2, MDM4, NAIP), DNA maintenance and processing (BAHCC1, FANCA, HIST1H3G, IK, KDM4C, MCM7, PRB3, RNASEH2B, SNRPE, TFDP2), signal transduction (ANXA2, ARHGAP19, C7orf47, CCDC50, DTX3, FHL2, P1K3CG, RALB, TICAM2), transport functions (ABCC1, FXYD2, S100A6, SCNN1C, XP05), oxidative stress response (SPATS2L, GSTT2B, NQ01), blood coagulation (FGA, MATR3, PROCR, PIK3CG), and others (ADAM22, ALDH3A2, FAM161A, HDDC2, HLA-F).
The six genes were phosphoinositide-3-kinase, catalytic, gamma polypeptide (PIK3CG); protein kinase, cAMP-dependent, regulatory, type II, alpha (PRKAR2A); AMP-activated protein kinase alpha 2 (AMPKA2); peroxisome proliferator activated receptor, gamma, coactivator 1 (PPARGC1); protein phosphatase 1, catalytic subunit, beta isoform (PPP1CB); and hormone-sensitive lipase (HSL).
In the same manner, some target genes demonstrated higher degree centrality with top 40 pathways, namely, PI3-kinase subunit gamma (PIK3CG, degree = 23), cAMP-dependent protein kinase catalytic subunit alpha (PRKACA, degree = 20), protein kinase C beta type (PRKCB, degree = 18), and calmodulin (CALM1, degree = 11).