Genes of diverse functional groups and signaling routes appeared: Cytoskleleton (BCL7A, DYNC1L12, SEFT10, SEPT11), transcriptional and translational regulation (DEPDC1, GABPB1, LHFPL2, NFIB, POLR3C, RPL34, RPS3A, RPS21, RPS25, TFDP2, TRIM24, ZBTB1, ZBTB38, ZFP112), cell death (CASP2, INC2, MDM4, NAIP), DNA maintenance and processing (BAHCC1, FANCA, HIST1H3G, IK, KDM4C, MCM7, PRB3, RNASEH2B, SNRPE, TFDP2), signal transduction (ANXA2, ARHGAP19, C7orf47, CCDC50, DTX3, FHL2, P1K3CG, RALB, TICAM2), transport functions (ABCC1, FXYD2, S100A6, SCNN1C, XP05), oxidative stress response (SPATS2L, GSTT2B, NQ01), blood coagulation (FGA, MATR3, PROCR, PIK3CG
), and others (ADAM22, ALDH3A2, FAM161A, HDDC2, HLA-F).
The six genes were phosphoinositide-3-kinase, catalytic, gamma polypeptide (PIK3CG
); protein kinase, cAMP-dependent, regulatory, type II, alpha (PRKAR2A); AMP-activated protein kinase alpha 2 (AMPKA2); peroxisome proliferator activated receptor, gamma, coactivator 1 (PPARGC1); protein phosphatase 1, catalytic subunit, beta isoform (PPP1CB); and hormone-sensitive lipase (HSL).
In the same manner, some target genes demonstrated higher degree centrality with top 40 pathways, namely, PI3-kinase subunit gamma (PIK3CG
, degree = 23), cAMP-dependent protein kinase catalytic subunit alpha (PRKACA, degree = 20), protein kinase C beta type (PRKCB, degree = 18), and calmodulin (CALM1, degree = 11).