PIK3CA

PIK3CA

A gene on chromosome 3q26.3 that encodes the 110-kDa catalytic subunit of phosphatidylinositol 3-kinase, which uses ATP to phosphorylate phosphatidylinositol, phosphatidylinositol4P and phosphatidylinositol(4,5)P2.
 
Molecular pathology
PIK3CA is oncogenic and been implicated in cervical cancers.
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References in periodicals archive ?
These data show shared somatic mutations between LCIS and invasive lobular carcinoma, most frequently of CDH1, PIK3CA, and CBFB genes.
FGFR3 and PIK3CA gene mutations have been found with the highest frequency in SKs, particularly familial SKs.
Nevertheless, different studies have shown association between iHME and mutations in AKT3, PIK3CA and MTOR genes.
0067 PRKAR1A, PPP1R3B, PHKG1, HK2, PPP1R3A, PIK3CA, PCK2, SHC3, PDPK1, AKT2 3 TPI1, MTMR7, PFKM, HK2 Ko00051 0.
Methods: A review of the literature revealed 60 mutation hotspots in seven target genes (EGFR, KRAS, PIK3CA, BRAF, ERBB2, NRAS, and BIM) that are closely related to EGFR TKI resistance to lung cancer.
Bu yontemle daha once bazi tanimlanmis genler olmakla beraber (TP53, PIK3CA, CDH1 ve PTEN gibi) yeni tanimlanacak genlerdeki anormalliklerin hem tanida hem de tedavide yonlendirici olabilecegi dusunulmektedir.
Papiller tumorler RAF/MEK/ERK ve PIK3CA yolagindaki genlerin degisimi ile ilgilidir (ornegin; FGFR3).
Droplet digital PCR (ddPCR) was used to validate TP53, PIK3CA, and estrogen receptor 1 (ESR1) mutations as described previously (8).
Switching of metabolism can be controlled by oncogenic pathways, such as the PI3K/AKT pathway, which is frequently activated in breast cancer through PIK3CA mutations.
The prognostic value of Microsatellite Instability, KRAS, BRAF and PIK3CA mutations in stage II colon cancer patients.
Other frequently found mutations in CIN include those in KRAS, P53, SMAD4 and PIK3CA [86].
Two of the most common oncogenes are PIK3CA (which promotes cell growth, survival, and motility) (9) and KRAS (which greatly increases cell glucose uptake).