PIGT | definition of PIGT by Medical dictionary
PIGT A gene on chromosome 20q12-q13.12 that encodes a component of the glycosylphosphatidylinositol (GPI) transamidase complex essential for the transfer of GPI to proteins.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive
A recent case of PNH caused by a germline mutation coupled with a somatic mutation in PIGT was reported .
Murakami et al., "A case of paroxysmal nocturnal hemoglobinuria caused by a germline mutation and a somatic mutation in PIGT," Blood, vol.
In this case PigT
regulator activates transcription of the biosynthetic operon pigA-O, but addition of gluconate decreases transcription of the latter.
(2013) A novel intellectual disability syndrome caused by GPI anchor deficiency due to homozygous mutations in PIGT