PIGR


Also found in: Acronyms.

PIGR

A gene on chromosome 1q31-q41 that encodes polymeric immunoglobulin receptor, which binds IgA or IgM at the basolateral surface of epithelial cells. As the IgA or IgM complex is transported across the cell for secretion at the apical surface, the extracellular (secretory) component is cleaved from the transmembrane macromolecule.
References in periodicals archive ?
They also demonstrated that biopsy specimens from IgAN patients were positively stained by antibody against the secretory component of PIGR. However, it is stated that these genetic associations had not generally been observed in any other population therefore, could not be proved to be involved in IgA nephropathy causation or progression (Maxwell and Wang, 2006).
Polymeric Ig receptor (pIgR) present on mucosal epithelial cells can bind to dimeric IgA and pentameric IgM.
S-IgA results from transcytosis of pIgA across the epithelium through binding to the pIgR. S-IgA is released from the pIgR by cleavage of the receptor, resulting in pIgA covalently associated with a substantial part of the pIgR, i.e., the secretory component (22).
Finally, expression of the pIgR and transcytosis of IgA dimers across IECs are impaired in the absence of MyD88 signaling [77].
One of the proteins we uncovered, termed PIGR, is of special interest, says Mann.
According to previously published techniques [33, 34], we obtained the full-length pIgR gene and pcDNA4/His A-pIgR [33].
The heavy and light chains produced in plasma cells were assembled into IgA, which is on association with polymeric immunoglobulin receptor (pIgR) during transcytosing across the basolateral epithelial cells lining on the mucosa.
The works include: - the construction of a bridge over the gardon, - the construction of a reduced-size lower bridge (pigr of sports avenue), - the creation of a retaining wall along avenue des sports, supporting upstream side, a path for soft modes, - the realization of rip raps on the banks of the river "le gardon", - the realization of the technical embankments contiguous to the works, - equipment on works, - pavements on structures and surroundings.
All these different forms are mainly found in the circulation, while secretory IgA (sIgA) is only found at mucosal surfaces and is generated by the binding of dimeric IgA via the J-chain to the polymeric immunoglobulin receptor (pIgR) at the basolateral side of the epithelium which is subsequently transported to the luminal side (Figures 1(d) and 1(e)).
Pigr.al Wall Clock (electronic) Electric kettle (Stainless Steel)
Contract award: prdp - rd775 - allaire connection / supply of rieux pigr du tertre payen.