PIGN

PIGN

A gene on chromosome 18q21.33 that encodes an ethanolamine phosphate transferase involved in glycosylphosphatidylinositol (GPI)-anchor and glycolipid biosynthesis.

Molecular pathology
Defects in PIGN cause multiple congenital anomalies-hypotonia-seizures syndrome type 1.
References in periodicals archive ?
2) The prototype of PIGN is Post-Streptococcal Glomerulonephritis (PSGN), which continues to be an important non-suppurative complication of Group A streptococcal infection.
7) The incidence of PIGN has decreased in the developed world, but in countries like India it is still an important public health problem.
All the case records of children up to 15 years of age, admitted to the hospital in the three-year period with final diagnosis of acute PIGN or PSGN were retrieved from the medical records department.
2011) Multiple congenital anomalies-hypotonia-seizures syndrome is caused by a mutation in PIGN.
2013) PIGN mutations cause congenital anomalies, developmental delay, hypotonia, epilepsy, and progressive cerebellar atrophy.
In six cases indication for biopsy was, active urine sediment with abrupt onset of proteinuria, the biopsy reports were turned out to be PIGN in two cases, MPGN type 1 in two cases, HIV associated nephropathy in one case, Membranous nephropathy in one case.