PIGM

PIGM

A gene on chromosome 1q32.2 that encodes a mannosyltransferase involved in glycosylphosphatidylinositol (GPI)-anchor and glycolipid biosynthesis.

Molecular pathology
Defects in PIGM cause GPI deficiency.
References in periodicals archive ?
I'm currently using the Biologique Recherche P50 PIGM 400, which is an acid toner aimed at pigmentation.
However, that mutant was not complemented by the PIGM cDNA.
Murakami demonstrated that the affected B-lymphoblastoid cells regained normal expression of GPI-APs after a 2-day culture in medium containing sodium butylate that inhibited histone deacetylases and increased acetylation of the PIGM promoter and transcription, which in turn increased PIG-M expression and GPI biosynthesis.