PIGF


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PIGF

A gene on chromosome 2p21-p16 that encodes a transmembrane protein involved in glycosylphosphatidylinositol-anchor biosynthesis. It forms a complex with PIGG and PIGO.
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High PIGF levels (>27 ng/L) in a single blood sample that was taken at presentation correlated with recurrences as well as with mortality within 1 month and 6 months of discharge.
1% of those with high PIGF levels had an adverse event within 72 hours, compared with a 4.
In the emergency room subjects, those with high PIGF levels had a 21.
High PIGF levels signaled increased cardiac risk in all patients regardless of whether they had undetectable, low, or high troponin T levels.
5 for later development of preterm preeclampsia among the women with PIGF concentrations in the lowest quartile (less than 118 pg/mL).
the upper three quartiles of PIGF concentration were 2.
If a reliable dipstick assay could be developed for urine screening of all pregnant women for urine PlGF, then subsequent serum measurements of both PIGF and sFlt-1 could minimize false-positive results from urine testing, the researchers said.
PIGF appears to be stable in circulation and must be considered a strong candidate as a biomarker for plaque instability, myocardial ischemia, and prognosis of patients in the spectrum of ACS.
Recombinant human PIGF is available commercially from several sources (e.
Particular interest in PIGF has been sparked by a proposed role as a principal instigator of atherosclerotic plaque instability, which is the physiologic common denominator for coronary artery thrombus formation and ACS (102).
Plasma PIGF measurements obtained at admission were investigated for assessing risk of death or nonfatal MI in the 30 days after index presentation in a large group of patients (n = 1173) (103).
PIGF is considered to be a marker, and PAPP-A is considered to be a potential marker, of atherosclerotic plaque instability2, 3.