PIGA


Also found in: Acronyms.

PIGA

A gene on chromosome Xp22.1 that encodes a transmembrane protein required for the synthesis of N-acetylglucosaminyl-phosphatidylinositol, a very early intermediate in GPI-anchor biosynthesis.

Molecular pathology
Defects in PIGA cause multiple congenital anomalies-hypotonia-seizures syndrome type 2 and paroxysmal nocturnal haemoglobinuria.
References in periodicals archive ?
Piga CA, Atzeni G (2007) R&D investment, credit rationing and sample selection.
Costa et al., "TSPO PIGA ligands promote neurosteroidogenesis and human astrocyte well-being," International Journal of Molecular Sciences, vol.
Composite flour knowledge has been used as a tool for extending short supplies of wheat and corn in the formulation of baked products (Okpala and Chinyelu, 2011; Piga et al., 2005).
Piga, Arsenic Leaching by Na2S to Decontaminate Tailings Coming from Colemanite Processing, Miner Eng, 16 45 (2003).
They are higher around Christmas, as Gaggero and Piga (2011) and Povoa and Oliveira (2013) show.
Piga e Vivarelli (2004) constatam uma situacao similar na Italia e identificam uma relacao entre as empresas publicas e a externalizacao de P&D junto a universidades e institutos de pesquisa fomentada pela disponibilidade de fundos publicos para este fim.
La microestructura de los huesos y dientes humanos sometidos al efecto del calor ha sido estudiada mediante diferentes tecnicas imagenologicas como la dispersion de rayos X de angulo pequeno (Sandholzer et al., 2014), la difraccion de rayos X (Piga et al., 2008), y mas recientemente, la micro-tomografia computerizada 3D (Sandholzer et al., 2013).
(1.) However, Keynes seems to have erred when he suggested that the work week would dwindle to only fifteen hours, a theme explored at length in Pecchi and Piga 2008.
The acquired mutation in PNH occurs in the phosphatidylinositol glycan anchor biosynthesis, class A (PIGA) gene, which is responsible for the first step in the synthesis of the glycosylphosphatidylinositol (GPI) anchor that attaches a subset of proteins to the cell surface [6].
If we think of larger cities as typically being more fractionalized ethnically, this result is in-line with the result of Cerqueti, Coppier, and Piga (2012), who show that the highest levels of corruption exist at the lowest and the highest levels of fractionalization.
FcaR1 is expressed on haematopoietic cells and when aberrant pIgA1 binds with FcaR1(CD89), it induces shedding of extracellular domain of FcaR1.After the cleavage of extracellular domain of FcaR1, it results in the release of pIgA / FcaR1complexes into the circulation and later on it get deposited in mesangium.