SPAG9

(redirected from PIG6)

SPAG9

A gene on chromosome 17q21.33 that encodes sperm-associated antigen 9, a member of the JNK-interacting protein (JIP) group of scaffold proteins, which selectively mediates JNK signalling by aggregating specific components of the MAPK cascade to form a functional JNK-signalling module.
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p53 then induces cell cycle arrest and apoptosis by inducing the expression of various target genes, including [p21.sup.WAF1], NOXA, and PIG6, leading to growth inhibition of damaged cells [8].
The following primers were used: human [p21.sup.waf1] forward 5'-GGCTTCATGCCAGCTACTTC-3' and reverse 5'-CCCTAGGCTGTGCTCACTTC-3'; human NOXA forward 5'-AGCTGGAAGTCGAGTGTGCT-3' and reverse 5'-ACGTGCACCTCCTGAGAAAA-3'; human PIG6 forward 5'-TTTTTCACCCCACACTTGCAGA-3' and reverse 5'-TGTCCCAGGCAGGTATCAGGTT-3'; human ROCK2 forward 5'-CAACTGTGAGGCTTGTATGAAG-3' and reverse 5'-TGCAAGGTGCTATAATCTCCTC-3'; and human ubiquitin forward 5'-TGACTACAACATCCAGAA-3' and reverse 5'-ATCTTTGCCTTGACATTC-3' [24].
To dissect whether p53 activation was involved in the ECM rigidity-dependent modulation of doxorubicin-induced cell growth inhibition, we examined p53 transcriptional activity by evaluating the expression of its well-known target genes, [p21.sup.Waf1], which encodes a cyclin-dependent kinase inhibitor, and NOXA and PIG6, whose products induce apoptosis by activating caspases [8].
Substrate Stiffness Influences Doxorubicin-Induced p53 Activation via ROCK2 Expression
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