PIAS1 | definition of PIAS1 by Medical dictionary
Also found in: Acronyms
PIAS1 A gene on 15q that encodes a member of the mammalian PIAS (protein inhibitor of activated STAT-1 [signal transducer and activator of transcription-1]) family, which inhibits STAT1-mediated gene activation and DNA binding activity; binds to Gu protein/RNA helicase II/DEAD box polypeptide 21; and interacts with androgen receptor (AR). It plays a key role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signalling pathway; it acts in the testis as a nuclear receptor transcriptional coregulator, and may have a role in AR initiation and maintenance of spermatogenesis.
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References in periodicals archive
Shuai, "Control of specificity and magnitude of NF-kappa B and STAT1-mediated gene activation through PIASy and PIAS1
cooperation," Proceedings of the National Academy of Sciences of the United States of America, vol.
Proinflammatory stimuli induce IKK[alpha]-mediated phosphorylation of PIAS1
to restrict inflammation and immunity.
Shuai, "The ligase PIAS1
restricts natural regulatory T cell differentiation by epigenetic repression," Science, vol.
It is now understood that ubiquitilation process plays important role in regulating DSB repair, and that perturbation of its control molecules including Small ubiquitin-related modifier (SUMO), E3 ligase (such as PIAS1
and PIAS4) may induce impaired DNA DSB repair .