SERPINB6

(redirected from PI6)

SERPINB6

A gene on chromosome 6p25 that encodes a member of the serine protease inhibitor (serpin) family, which was first described as a placental thrombin inhibitor. SERPINB6 inhibits cathepsin G, kallikrein-8 and thrombin, and may play an important role in protecting the inner ear against leakage of lysosomal content during stress.

Molecular pathology
SERPINB6 mutations are associated with nonsyndromic progressive hearing loss.
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References in periodicals archive ?
There do exist direct relations between the numerators (and the denominators) of the different PIs, however, like between the numerators (and denominators) of PI6 and PI1 unto PI5, and the numerator (and denominator) of PI8 and the numerator (and denominator) of the set of PI7s.
Thereafter (measure 159), the manuals begin the dramatic ascent to the highest notes of the piece, each hand playing primarily in disjunct tetrachords voiced as interlocked pi5s, pi6s and pi7s.