Fardella et al., "Lack of kinase-independent activity of PI3Kgamma in locus coeruleus induces ADHD symptoms through increased CREB signaling," EMBO Molecular Medicine, vol.
Sim et al., "PI3Kgamma is required for NMDA receptor-dependent long-term depression and behavioral flexibility," Nature Neuroscience, vol.
Naga Prasad, "Inhibition of protein phosphatase 2A activity by PI3Kgamma
regulates beta-adrenergic receptor function," Molecular Cell, vol.
Diacovo, "Role of PI3Kdelta and PI3Kgamma
in inflammatory arthritis and tissue localization of neutrophils," European Journal of Immunology, vol.
is a key regulator of inflammatory responses and cardiovascular homeostasis.
Protection from angiotensin II-mediated vasculotoxic and hypertensive response in mice lacking PI3Kgamma
. J Exp Med 2005; 201: 1217-1228, doi: 10.1084/jem.20040995.
Along with his colleagues, Professor Shaun McColl and PhD students Wendel Litchfield and Ervin Kara, he focused on a molecule known as PI3Kgamma, which is involved in the activation and movement of white blood cells.
"There's already been worldwide interest in PI3Kgamma in relation to other human inflammatory disorders, such as diabetes and rheumatoid arthritis, and our study links this molecule and MS," Dr Comerford said.
Following up on this result, the team then used an orally active drug that blocks the activity of the molecule PI3Kgamma at the first signs of disease onset.