PIK3CA

(redirected from PI3K-alpha)

PIK3CA

A gene on chromosome 3q26.3 that encodes the 110-kDa catalytic subunit of phosphatidylinositol 3-kinase, which uses ATP to phosphorylate phosphatidylinositol, phosphatidylinositol4P and phosphatidylinositol(4,5)P2.
 
Molecular pathology
PIK3CA is oncogenic and been implicated in cervical cancers.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
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The company added that Aliqopa is an intravenous phosphatidylinositol-3-kinase (PI3K) inhibitor with inhibitory activity predominantly against the PI3K-alpha and PI3K-delta isoforms expressed in malignant B cells.
According to the company, Aliqopa is a novel intravenous PI3K inhibitor with inhibitory activity predominantly against the PI3K-alpha and PI3K-delta isoforms expressed in malignant B cells.
CUDC-907 is designed to inhibit HDACs 1, 2, 3, 6 and 10 and PI3K-alpha, delta and beta isoforms, the combined inhibition that has synergistic effects against cancer cells and their microenvironment.
The combined inhibition of CUDC-907 is expected to have synergistic effects against cancer cells and their microenvironment, and is aimed at inhibiting PI3K-alpha, delta and beta isoforms and HDACs 1, 2, 3, 6 and 10.