PIK3CA

(redirected from PI3K-alpha)

PIK3CA

A gene on chromosome 3q26.3 that encodes the 110-kDa catalytic subunit of phosphatidylinositol 3-kinase, which uses ATP to phosphorylate phosphatidylinositol, phosphatidylinositol4P and phosphatidylinositol(4,5)P2.
 
Molecular pathology
PIK3CA is oncogenic and been implicated in cervical cancers.
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References in periodicals archive ?
Copanlisib is a pan-Class I phosphatidylinositol-3-kinase (PI3K) inhibitor with predominant inhibitory activity against both PI3K-alpha and PI3K-delta isoforms.
Currently in clinical Phase II, copanlisib is a novel PI3K-alpha, delta-inhibitor with promising early clinical signal in a Phase I study in heavily pretreated patients with follicular and diffuse large B cell lymphoma.