SERPINI1

(redirected from PI-12)

SERPINI1

A gene on chromosome 3q26.1 that encodes a member of the serpin superfamily of serine proteinase inhibitors that inhibits tissue-type plasminogen activator. It is secreted by axons in the brain and thought to play a role in regulating axonal growth and the development of synaptic plasticity or the reorganisation of synaptic connections. SERPINI1 may protect neurons from cell damage by tissue-type plasminogen activator.

Molecular pathology
SERPINI1 mutations cause familial encephalopathy with neuroserpin inclusion bodies (FENIB), an autosomal dominant form of familial encephalopathy and epilepsy.
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The expected outcomes are: (i) an increase in tax revenue, from 16.9% of GDP in 2013 to 17% in 2015 and 20% in 2018; (ii) an increase in the share of mining revenue in total public revenue, from 4.8% of GDP in 2011 to 6% in 2015 and 6.5% in 2018; (iii) improvement in PEFA PI-12 indicator of a multi-year perspective in budgeting and public expenditure policies, from D in PEFA 2009 to C in PEFA 2015 and B in PEFA2018; and (iv) an increase in the number of young volunteers mobilized each year, from 1 500 in 2012 to 2 000 in 2015 and 2 500 in 2018.