pulmonary hypertension, primary, type 1

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pulmonary hypertension, primary, type 1

A rare disorder (OMIM:178600) characterised by plexiform lesions of proliferating endothelial cells in pulmonary arterioles, leading to elevated pulmonary arterial pressure, right ventricular failure and death. The disease can occur at any age from infancy onward, but has a mean age of onset at 36 years. Cases secondary to known aetiologies are the more common cause of pulmonary hypertension, and include those associated with appetite-suppressant drugs.

Molecular pathology
May be caused by defects of SMAD9, which encodes a receptor-regulated SMAD, transducing signals from TGF-beta family members.
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[10] There is renewed interest in the treatment of PHT because of effective pulmonary vasodilators like Sildenafil, tadalafil, Bosentan and Ambrisentan which are available worldwide.
Theorized alternative mechanisms for PLCH-related PHT include the elaboration of cytokines by the Langerhans cells of PLCH, which may exert both localized and potentially widespread vascular remodeling.
In our clinical experience, it is clear that TB does not end with cessation of treatment, and long after the current epidemic is over we may be left with a generation of individuals still suffering long-term consequences, one of which is PHT.
Asiana Airlines OZ 710 (Cebu to Incheon, South Korea) - Last scheduled departing international flight before transition 02:00 Hrs PHT.
The PHT portfolio is one of the largest medical office asset sales to have occurred.
The aim of the present study was to develop and validate an LC-MS/MS method for the measurement of PHT concentrations in different body compartments such as blood and saliva, as well as samples from brain tissue microdialysis often used in neurology and neurosurgery, where antiepileptic therapy is often mandatory [11,12], and to compare its efficiency with a formerly developed GC-MS method [8].
Manipulation of aerobic exercise intensity (11,20,22) and exercise type such as cycle and arm ergometry (1) have been investigated in NT (11,22) and PHT (20) individuals.
That means the PHT and the bitmatrix can effectively improve the detection accuracy.
27 February 2015 - US-based clinical trial technology specialist ERT and US-based clinical research technology company PHT Corp.
M2 PHARMA-February 18, 2015-New PHT Apps Aim to Increase Patient Retention, Compliance in Clinical Trials
PHT Corporation has introduced the clinical version of the C-SSRS on the SitePad tablet, enabling clinicians and study staff to electronically assess suicidal ideation and behavior in clinical trial participants.