EGLN2

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EGLN2

A gene on chromosome 19q13.2 that encodes a cellular oxygen sensor which catalyses, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. It is involved in regulating hypoxia tolerance, susceptibility to normoxic oxidative neuronal death and apoptosis in cardiac and skeletal muscle.

EGLN2 hydroxylates a specific proline found in each oxygen-dependent degradation (ODD) domains—N-terminal (NODD) and C-terminal (CODD)—of HIF1A; hydroxylated HIFs are then targeted for proteasomal degradation by the von Hippel-Lindau ubiquitination complex. During hypoxia, the hydroxylation reaction is attenuated, allowing HIFs to escape degradation, resulting in translocation to the nucleus, heterodimerisation with HIF1B and increased expression of hypoxy-inducible genes.
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It took over that project from PHD1 Construction, which went into administration the year before.
Knockout of the gene encoding PHD1, an inhibitor of the HIF signaling, drives macrophages towards an anti-inflammatory M2 phenotype and attenuates IL-1b production in dendritic cells in response to lipopolysaccharide [93].
These include hypoxia-inducible factor 2 alpha (HIF2A), fumarate hydratase (FH), prolyl hydroxylase types 1 and 2 (PHD1 and PHD2), Harvey rat sarcoma viral oncogene homolog (HRAS), kinesin family member 1B (KIF1B), and X-linked alpha thalassemia mental retardation (ATRX) genes [16-20].
(97-98) The PHD family comprises subtypes PHD1, PHD2 and PHD3, which require [O.sub.2] as a cofactor for their enzymatic activity.
The project's builders, PHD1 - who went into administration last year - once described Liverpool property magnate Peter McInnes as their chairman.
P Skowno, PhD1, W Derman, MBChB, FFIMS, PhD2, D J Stein, MBChB, FRCPC, PhD3, C E Draper, PhD1
The cases PHD1, PHD2, and PHD3 with a risk for manifest chorea within little time presented with P2 latency in the upper normal limits.
We have reported earlier that even under normal oxygen level EBNA3 binds to PHD2 and EBNA5 to PHD1, thus, inactivating both enzymes.
(28.) Ranjan Kumar Prusty, Reproductive Tract Infections and Treatment Seeking Behavior among Married Adolescent Women in India MPS1; Sayeed Unisa, PhD1 Paper to be presented at XXVII IUSSP Conference 2013, Busan, South Korea.
The four-bedroom, 3,433 s/f PHD1 is listed at $7.75 million, although there is a two bedroom available for $2.48 million.
PHD1 Studios is taking talented Huddersfield bands on a tour of West Yorkshire.