UCHL1

(redirected from PGP9.5)

UCHL1

A gene on chromosome 4p14 that encodes a ubiquitin-protein hydrolase, involved both in processing of ubiquitin precursors and ubiquitinated proteins, which recognises and hydrolyses a peptide bond at the C-terminal glycine of ubiquitin. UCHL1 also binds free monoubiquitin and may prevent its degradation in lysosomes.
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References in periodicals archive ?
After sections were stained with FITC-labeled tyramide for PGP9.5, TH or VIP, sections were incubated, respectively, with mouse anti-K7 (ZSGB-BIO, ZM0071, Beijing, China), rabbit ani-S100P (Novus, NBP1-95671, MO, USA), or rabbit ani-K14 (ZSGB-BIO, ZA0540, Beijing, China) for 2 h at room temperature in the dark, followed by incubation with Cy3-labeled goat anti-rabbit (Beyotime, A0516, Jiangsu, China) or Cy3-labeled goat anti-mouse (Beyotime, A0521, Jiangsu, China) secondary antibodies for 10 min at room temperature in the dark.
Assessing the interstitial cells of Cajal, cells of enteric nervous system and neurotransmitters in slow transit constipation, using immunohistochemistry for CD117, PGP9.5 and serotonin.
The tumor cells of the polypoid tumors were positive for pancytokeratin, synaptophysin, chromogranin A, CD57, protein gene protein 9.5 (PGP9.5), and Ki67 (2% of labeled cells) (Figure 3).
The lesion was positive for PTH (confirming the parathyroid origin) and was negative for galectin-3 and PGP9.5. There was no loss of expression for parafibromin, Rb, p27, and bcl-2.
The noteworthy or emerging markers mentioned in this review include S100, mammaglobin, vimentin, EMA, and balanced translocation t(12;15)(p13;q25) for mammary-analog secretory carcinoma; microphthalmia-associated transcription factor (MITF) and SOX10 for mucosal melanoma; diffusely positive p40 and p63 for basaloid squamous cell carcinoma; p63, Epstein-Barr virus-encoded small RNA (EBER), and latent membrane protein 1 (LMP-1) for nasopharyngeal carcinoma; loss of parafibromin, galectin3 overexpression, increased Ki-67 index, and expression of protein gene product 9.5 (PGP9.5) for parathyroid carcinoma (versus adenoma); and EMA, CK, and CD117 labeling epithelial cells and p63, smooth muscle actin (SMA), and S100 labeling myoepithelial cells for epithelial-myoepithelial carcinoma.
(4) Morgen et al (12) stated that calponin, CD10, and protein gene product 9.5 (PGP9.5) were positive in their cases of head and neck NF in addition to SMA.
However, protein gene product 9.5 (PGP9.5: a marker protein of peripheral nerve fibers), immunoreactive (ir) intraepithelial nerve fibers or terminals decreased, causing a reduction of eye wiping by fourth-sixth to that of control by instillation of 100 [micro]M capsaicin onto the cornea [12].
Akhondi et al., "Isolation, identification, and culture of goat spermatogonial stem cells using c-kit and PGP9.5 markers," Journal of Assisted Reproduction and Genetics, vol.
Oct-4 (also as knows Pou5fl), THY-1, c-kit, PGP9.5 (also as knows UCHL-1) and Dolichos biflorus agglutinin (DBA) are used to identify bovine (Izadyar et al., 2002; Oatley et al., 2004; Reding et al., 2010), goat (Heidari et al., 2012; Abbasi et al., 2013), sheep (Rodriguez-Sosa et al., 2006), pig (Lee et al., 2013; Lee et al., 2014), dog (Harkey et al., 2013), mouse and human (von Kopylow et al., 2010) and chicken SSCs (Momeni-Moghaddam et al., 2014; Sisakhtnezhad et al., 2015).
Stains used in the rectal biopsies include Haematoxylin and Eosin, Acetylcholine esterase on the frozen sections, Nicotinamide adenine dinucleotide phosphate diaphorase (NADPH-d), Nitric oxide synthase (NOS), Peripherin and c-kit, Calretinin, antibodies to neurofilament 68 and tubulin, protein gene product 9.5 (PGP9.5), antigen CD56 (CD56), Cathepsin D, RET, BMPR1A, and bcl-2 immunohistochemistry can be used.
The difference of percentage of undifferentiated SSCs (PGP9.5 positive) in each method was compared using ANOVA and comparison between the highest percentage of corresponding value between two methods was carried out by t-test using Sigma Stat (ver.
Interestingly, expression of Pgp9.5, a neuro-endocrine marker and component of the cardiac conduction system (El Sharaby et al.