UCHL1

(redirected from PGP9.5)

UCHL1

A gene on chromosome 4p14 that encodes a ubiquitin-protein hydrolase, involved both in processing of ubiquitin precursors and ubiquitinated proteins, which recognises and hydrolyses a peptide bond at the C-terminal glycine of ubiquitin. UCHL1 also binds free monoubiquitin and may prevent its degradation in lysosomes.
References in periodicals archive ?
There is variable expression of other neuroectodermal antigens including NSE (positive in this case), synaptophysin, neurofilament, GFAP and PGP9.
Briefly, cells and colonies were fixed with 4% PFA and methanol, and incubated with appropriate dilutions of mouse monoclonal antibodies against PGP9.
24% of cells in 45-60% and 30-45% Percoll layers, respectively were positive for PGP9.
70% of cells, enriched by differential plating method, were positive for PGP9.
To confirm the purity of these putative pigSSC colonies, we isolated mRNA from these colonies and performed RT-PCR with primer pairs specific for PGP9.
These cell colonies displayed morphology similar to that reported previously for miceSSC and were positive for SSC markers such as PGP9.
This is the first demonstration of antibodies to pro-MMP-7 in cancer patients, although numerous circulating antitumor antibodies have been detected in cancer patient sera, with identified antigens such as Her2/neu (32), thymidine phosphorylase (16), and PGP9.
We have developed a culture process which allows in vitro expansion of adult human pancreatic cells, including insulin, glucagon, Ngn3, Pax4, and PGP9.
Immunostains showed the tumour cells were negative for chromogranin, CK7, CK20, PGP9.
Four of the 6 monophasic synovial sarcomas exhibited 3+ immunoreactivity to PGP9.
5) Using polyclonal and monoclonal antibodies, Wilson et al (6) demonstrated that PGP9.
One case, being a uterine leiomyosarcoma, demonstrated strong PGP9.