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16,38-40) Our study clearly demonstrates that PGE2 is one of multiple lipid mediators produced by diseased cartilage, including molecules that have been associated with important roles in other tissues, such as PGD2, PGI2, and LTB4.
16,17) Las prostaglandinas (PGs) que son las mas importantes del rinon son PGE2 y PGI2 o prostaciclina.
Vasodilation effects of EOFAZ were totally abolished by mechanical removal of the endothelium, suggesting that they are dependent upon released endothelium-derived relaxant factors such as nitric oxide (NO), PGI2 and/or endothelium-derived hyperpolarizing factor (EDHF).
Esses farmacos diminuem a producao de prostaglandina vascular, com isso ocorre um desequilibrio de TXA2 e PGI2, o que justifica o aumento de problemas tromboticos e cardiovasculares.
Os AINEs COX-2 seletivos reduzem a formacao de PGI2 pelas celulas endoteliais, consequentemente rompendo o equilibrio entre TXA2 e PGI2 e potencialmente favorecendo eventos protromboticos cardiovasculares (FRESNO et al.
Existe una probable estimulacion del SRAA a la via de las caspasas, que son enzimas proapoptoticas sobre las celulas eritropoyeticas y vasoconstrictoras, por un bloqueo de la PGI2 y el NO (18).
In this experiment, after the aortic rings were preincubated with Indo, an inhibitor of cyclooxygenase, the vasodilator effect caused by EOFAZ was not change which indicated the PGI2 route might not be one of the mechanisms of the vasorelaxation caused by EOFAZ.
More than a decade ago, inhibition of cyclooxygenase-2 (COX-2) by the nonsteroidal anti-inflammatory drugs (NSAIDs) rofecoxib (Vioxx) and celecoxib (Celebrex) was found to reduce the amount of the major metabolite of PGI2 in the urine of healthy volunteers.
l[alpha]], no direct effect of DDKA was observed, indicating that the antithrombotic action of DDKA may not be mediated via the arachidonic acid cascade, for PGI2 and TXA2 are products of arachidonic acid (AA) metabolism by cyclooxyge-nase (COX) (Tanaka et al.
2-5) Fish oils increased platelet aggregation by reducing PGI2 (prostacyclin), which increases platelet disaggregation, by 42%.