prostacyclin

(redirected from PGI2)
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Related to PGI2: prostaglandin, PGF2, PGD2

prostacyclin

 [pros″tah-si´klin]
a prostaglandin, PGI2, synthesized by endothelial cells lining the walls of arteries and veins; it is a potent vasodilator and a potent inhibitor of platelet aggregation. When used pharmaceutically it is called epoprostenol.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

pros·ta·cy·clin

(pros'tă-sī'klin),
A potent natural inhibitor of platelet aggregation and a powerful vasodilator.
Farlex Partner Medical Dictionary © Farlex 2012

prostacyclin

(prŏs′tə-sī′klĭn)
n.
A prostaglandin produced in the walls of blood vessels that acts as a vasodilator and inhibits platelet aggregation.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

pros·ta·cy·clin

(pros'tă-sī'klin)
A potent natural inhibitor of platelet aggregation and a powerful vasodilator.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

prostacyclin

A short-acting hormone produced by the lining of blood vessels (ENDOTHELIUM) and by the lungs, that limits the aggregation of PLATELETS and is probably of major importance in preventing THROMBOSIS. Prostacyclin has a half-life of only 2–3 minutes.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

pros·ta·cy·clin

(pros'tă-sī'klin)
A potent natural inhibitor of platelet aggregation and a powerful vasodilator.
Medical Dictionary for the Dental Professions © Farlex 2012
References in periodicals archive ?
The production of prostaglandin endoperoxides from arachadonic acid in the endothelium, specifically PGI2, stimulates adenylyl cyclase to convert adenosine triphosphate (ATP) to cyclic adenosine monophosphate (cAMP), which also facilitates pulmonary vasodilatation.
As described previously, NSAIDs inhibit prostaglandin synthesis (e.g., PGI2 and PGE2) in the kidneys.
By contrast, the effects of ET-1 on the ETB receptor result in the release of NO and PGI2 from the endothelium.
(c) Fish oil decreases critical prostacyclin (PGI2) in patients with atherosclerosis--a very bad outcome.
Muller-Delp, "Exercise training enhances flow-induced vasodilation in skeletal muscle resistance arteries of aged rats: role of PGI2 and nitric oxide," American Journal of Physiology: Heart and Circulatory Physiology, vol.
Among five prostanoids of PGE2, PGD2, PGI2, PGF2[alpha], and thromboxane (TX) A2, PGI2 and TXA2 are important players in regulation of renal hemodynamics [5-7]; PGE2 serves as an important regulator of glomerular integrity, SS hemodynamics, and tubular fluid reabsorption [8-10], while the PGD2 and PGF2[alpha] in kidney are less studied and their functions are poorly understood.
Endothelial cells play a crucial part in BP homeostasis through the synthesis of vasodilators such as nitric oxide (NO), prostacyclin (PGI2), and endothelium-derived hyperpolarising factor (EDHF) and vasoconstrictors such as endothelin-1, thromboxane (TXA2), and angiotensin II.
La agregacion plaquetaria tambien es constantemente inhibida por productos secretados por el endotelio sano: oxido nitrico, prostaciclina (PGI2, la cual ejerce funcion contraria al tromboxano A2) y la ecto-ADP-asa, que degrada el ADP circulante [36].
A COX-2 nao esta expressa de modo constitutivo, a excecao de sua participacao fisiologica na producao de PGI2, de modo que apresenta sua sintese induzida mediante a ocorrencia do processo inflamatorio, originando diversos prostanoides como as prostaglandinas que potencializam eventos como a vasodilatacao.
In addition, evidence is accumulating that ACE itself can act as a cell-surface receptor and that binding of an ACE inhibitor to the enzyme triggers a signaling cascade that leads ultimately to PGI2 generation and additional vasodilatory effects.