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name given to prostaglandin E2 when used pharmaceutically; used as an oxytocic for induction of abortion or of labor, to evacuate the uterus in the management of missed abortion, to aid ripening of the cervix prior to the induction of labor, and in the treatment of hydatidiform mole; administered intravaginally or intracervically.

dinoprostone (prostaglandin E2, PGE2)

Cervidil Vaginal Insert, Prepidil Endocervical Gel, Propress (UK), Prostin E2 Vaginal Suppository

Pharmacologic class: Oxytocic, prostaglandin

Therapeutic class: Abortifacient, cervical ripening agent

Pregnancy risk category C

FDA Box Warning

• Dinoprostone vaginal suppository should be given only by trained personnel who adhere strictly to recommended dosages, in hospital that can provide immediate intensive care and acute surgical facilities.


Initiates strong contractions of uterine smooth muscle by stimulating myometrium and promoting cervical softening, effacement, and dilation


Endocervical gel: 0.5 mg in 3-g gel vehicle in prefilled syringe with catheter

Vaginal insert: 10 mg

Vaginal suppositories: 20 mg

Indications and dosages

Cervical ripening

Adults: 0.5 mg endocervical gel vaginally; if response is poor, may repeat in 6 hours (not to exceed 1.5 mg in 24 hours). Or one 10-mg vaginal insert.

To induce abortion

Adults: One 20-mg vaginal suppository; repeat q 3 to 5 hours (not to exceed total dosage of 240 mg or duration of 48 hours).

Nonmetastatic gestational trophoblastic disease (benign hydatidiform mole)

Adults: Insert one 20-mg suppository high into vagina; may repeat at 3- to 5-hour intervals for up to 2 days if necessary.


• Hypersensitivity to prostaglandins or additives in gel or suppository

• When vaginal delivery isn't indicated, such as with vasa previa or active genital herpes infection (Prepidil)

• Acute pelvic inflammatory disease

• Ruptured membranes, placenta previa, marked cephalopelvic disproportion, or unexplained vaginal bleeding during pregnancy

• When oxytocics are contraindicated or when prolonged contraction of uterus may be detrimental to fetal safety or uterine integrity, such as with previous cesarean section or major uterine surgery

• Concurrent use of I.V. oxytocics (Cervidil)

• Clinical suspicion or definite evidence of fetal distress when delivery isn't imminent (Cervidil, Prepidil)

• History of difficult labor or traumatic delivery, hyperactive or hypertonic uterine patterns (Prepidil)

• Obstetric emergencies in which benefit-to-risk ratio for either fetus or mother favors surgical intervention (Prepidil)

• Active cardiac, pulmonary, renal, or hepatic disease (Prostin E2 Vaginal Suppository)

• Multipara with six or more previous term pregnancies (Cervidil)

• Grand multipara with six or more previous term pregnancies with non-vertex presentation (Prepidil)


Use cautiously in:

• history of pulmonary, cardiac, renal, or hepatic disease; asthma; jaundice, anemia; cervicitis; infected endocervical lesions; acute vaginitis; compromised (scarred) uterus; hypertension; hypotension; adrenal disorders; diabetes mellitus; epilepsy; glaucoma

• women age 30 or older, those with complications during pregnancy, and those with gestational age of more than 40 weeks are at increased risk of post-partum disseminated intravascular coagulation

• concurrent use of other oxytocics (not recommended).


• Keep patient supine for 15 to 30 minutes after gel administration and for 10 minutes after administering suppository to prevent drug expulsion.

• Store suppositories in freezer; bring to room temperature before using.

Adverse reactions

CNS: headache, drowsiness, syncope

CV: hypotension, hypertension

GI: nausea, vomiting, diarrhea

GU: urinary tract infection, vaginal or uterine pain, uterine contractile abnormalities, warm vaginal sensation, uterine hypertonicity, uterine rupture

Musculoskeletal: back pain

Respiratory: cough, dyspnea, wheezing

Other: allergic reactions including chills, fever, and anaphylaxis


Drug-drug. Other oxytocics: increased oxytocic effects

Patient monitoring

Monitor uterine contractions and observe for excessive vaginal bleeding and cramping. Record sanitary pad count.

• Monitor vital signs and assess for drug-induced fever. Report significant blood pressure and pulse changes.

• Assess for wheezing, chest pain, and dyspnea.

• Evaluate for GI upset. To minimize, give antiemetic before dinoprostone therapy.

Patient teaching

• Advise patient to stay in supine position, as prescribed, after administration.

• Instruct patient to report fever, bleeding, or abdominal cramps.

• Tell patient to avoid douches, tampons, tub baths, and sexual intercourse for at least 2 weeks after receiving drug.

• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs mentioned above.


/di·no·prost·one/ (di″no-pros´tōn) name given to prostaglandin E when used pharmaceutically; used as an oxytocic for induction of abortion or labor, to aid ripening of the cervix, and in the treatment of missed abortion or hydatidiform mole.


A PROSTAGLANDIN drug used by injection into the uterus to induce labour. Brand names are Prepidil, Propess-RS and Prostin E2.
References in periodicals archive ?
Certain patients and tumor types have higher expression of PGE2-related molecules and/or immune characteristics that are more likely to respond to PGE2 receptor blockade, presenting an opportunity for patient stratification to improve outcomes.
They found that muscle stem cells that had undergone injury displayed an increase in the expression of a gene encoding for a receptor called EP4, which binds to PGE2.
It has been noticed in routine as well as through literature that PGE2 is a more effective method for induction of labor and has benefits in terms of early spontaneous delivery without compromising the health of fetus and mother.
In induction group (B), induction was successful with single application of PGE2 in 41 (56.
The primary data on potential to reduce leukotriene B4, TXB2 and PGE2 synthesis [11] and antiinflammatory properties of heparin has been observed in many experiments [1,20, 21].
Identification of specific EP receptors responsible for the hemodynamic effects of PGE2," American Journal of Physiology--Heart and Circulatory Physiology, vol.
Under the conditions of neuronal damage and repair, the long-term mast cell PGE2 response to NGF could provide a mechanism by which locally harmful responses might be limited.
Prof Caetano Reis e Sousa said blocking the molecule PGE2 would "lift this protective barrier and unleash the full power of the immune system", helping deliver "life-changing results".
La actividad de COX-2 y de la PGE2 sintetizada por la misma, son reguladores positivos de la proliferacion en celulas tumorales asi como supresores de apoptosis promoviendo el desarrollo del tejido neoplasico [23].
Produced by many cell types, PGE2 has been shown to affect various aspects of the immune and inflammatory responses by acting on all components of the immune system (Hedi, 2013).
The mechanism and purpose of acute phase response are unknown but copper may have anti- inflammatory role, so that raised copper levels are actually protective in function, inhibiting production of the inflammatory prostaglandins like PGE2 and perhaps stimulating antiinflammatory prostaglandin PGF2.