There is a growing body of data suggesting that an isolated PFO or ASA is not associated with increased risk of primary stroke, and no specific treatment is typically needed in someone who is asymptomatic.
This vortex formed at the right atrium entrance is thought to remove the blood out of PFO which carries the majority of thrombus material, bubble, vasoactive chemicals and which is coming with the inferior caval current directed at almost to the fossa ovalis at the beginning which (7,8).
Most people with a PFO, a hole occurring in the upper wall between the left and right atria of the heart, do not experience any issues when blood flows from one atrium to the other; however, serious problems including stroke can arise if a blood clot passes from the right to left atria through a PFO and then to the brain.
Paradoxical embolism originating from a venous source has been identified as a potential cause of stroke/TIA in patients with PFO. The association of paradoxical embolism and cryptogenic stroke/TIA is backed up by the fact that a higher prevalence of PFO has been documented in patients with cryptogenic stroke (up to 56%) as compared to the general population (20 to 26%) [4-7].