PF4


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PF4

A gene on chromosome 4q12-q21 that encodes a protein released from the alpha-granules of activated platelets which binds with high affinity to heparin. PF4’s major physiologic role appears to be neutralisation of heparin-like molecules on the endothelial surface of blood vessels, inhibiting antithrombin-III activity and promoting coagulation; as a chemoattractant for neutrophils and fibroblasts, PF4 likely plays a role in inflammation and wound repair.
References in periodicals archive ?
Measurements of plasma levels of PF 4 have been shown to be the marker of platelet degranulation and increased level of PF4 is used to detect platelet activation of the circulating pool of platelets [35].
In conclusion, this report is the first to reveal that ICs containing TSP-1 or PF4 are present specifically in the serum of RA patients, and these ICs may have po tential as alternative biomarkers for the diagnosis of RA.
To determine if your patient has HIT, a PF4 antibody must be checked.
Comparison of Two Forms of Heparin UFH LMWH Inexpensive (7) Expensive (7) Non-specific binding Lacks non-specific binding Binds PF4 (6) Less efficient binding of PF4 (6) 1/2 life--60 min (IV, longer SC) (1) 1/2 life 3-6 hours (SC) (1) Neutralized by protamine (1,3,5) Not fully normalized by protamine (1) Monitor with APTT No need to monitor HIT (porcine mucosa) 4.
PF4 activa a los linfocitos T via quimioquina CXCR3; asi estimula la secrecion de citoquinas y favorece la inflamacion (81).
In both our patients, the appearance of antiplatelet antibodies was confirmed with direct and indirect platelet microimmunoflouroscence test for the heparin antibodies formation (ID-Card Heparin/ PF4 antibody test[R], DiaMed AG, France), and in both patients tests were repeated daily and were highly positive.
Six genes were selected for confirmation by real-time PCR, and of these, CXCL16, ZNF331, JUN, and PF4 were the most significantly affected by benzene exposure, a finding that was confirmed in a larger data set from 28 subjects.
44] Several platelet proteins/chemokines were proposed as the putative receptors of heparin-dependent antibodies,[45] and PF4 was identified as the main cofactor.
This PF4 face conveyor is 1,332 mm wide with two 42 x 146 mm TIB chains.
The researchers believe that once injected into the tumor, the adenovirus infects many types of cells and makes each one crank out the PF4 gene's protein.