PEX6

PEX6

A gene on chromosome 12p13.31 that encodes peroxin-6, a member of the AAA family of ATPases, which are integral membrane proteins involved in peroxisome biosynthesis and integrity. 

Molecular pathology
PEX6 mutations are associated with peroxisome biogenesis disorders of complementation group 4 and complementation group 6.
References in periodicals archive ?
Hettema, "Deficiency of the exportomer components Pex1, Pex6, and Pex15 causes enhanced pexophagy in Saccharomyces cerevisiae," Autophagy, vol.
A more practical approach, i.e., a transient expression assay skipping the revertant selection by P12/UV, (39) was also developed for further isolation of PEX cDNAs including nine others, PEX1, PEX3, PEX5, PEX6, PEX12, PEX13, PEX14, PEX19, and PEX26 (21), (34), (40)-(48) (Table 3; Fig.
An alternative strategy, i.e., the homology search by screening the expressed sequence tag database using yeast PEX genes, successfully made it feasible to isolate human orthologue genes responsible for PBDs: (22), (24), (34) PEX1, (55), (56) PEX3, (57) PEX5, (58) PEX6, (59) PEX7, (60)-(62) PEX10, (63),(64) PEX12, (65) PEX13, (66) PEX14, (67) and PEX16.
(2012) AWP1/ZFAND6 functions in Pex5 export by interacting with Cys-mono-ubiquitinated Pex5 and Pex6 AAA ATPase.