PEX3

PEX3

A gene on chromosome 6q24.2 that encodes a peroxin, an integral membrane protein involved in peroxisome biosynthesis and integrity, which assembles membrane vesicles before translocation of matrix proteins.
 
Molecular pathology
PEX3 mutations are associated with a variant of  Zellweger syndrome.
References in periodicals archive ?
Meanwhile, French container shipping giant CMA CGM will begin serving Port Tampa Bay in late May on its Pacific Express 3 (PEX3) service.
Index Gene selection Description 5890 AJ001625 Homosapiens mRNA for Pex3 protein [28] 6462 M11433 Human cellular retinol-binding protein mRNA, complete cds [29] 9172 AI207842 Ao89h09.x1 Homosapiens cDNA, 3 ends [30] 9850 M84526 Human adipsin/complement factor D mRNA, complete cds [29] 12495 M98539 Human prostaglandin D2 synthase gene, exon 7 [29] Note.
CMA CGM has called at the Port of New Orleans since 2009 and currently operates three weekly services, the Med-Americas Service to the Caribbean and South and Central American ports from New Orleans, the Victory Bridge Service to Northern European ports and the PEX3 service, a direct weekly service to Asia.
Gene expression comparison among affected and unaffected areas and normal scalp shows that some genes are downregulated in hair follicle cycling, lipid homeostasis, and peroxisome biogenesis, including PEX3 and PEX16, and some genes involved in the inflammatory cascade and apoptotic pathways are upregulated.
They require peroxins (PEXs) for their biogenesis, especially PEX3 and PEX16, which are both quite specific to PPAR-[gamma].
In budding yeast, the specific adaptor for pexophagy is Atg36, which directly interacts with the peroxisomal Pex3 protein and the core phagosomal components Atg11 and Atg8 [177, 178].
Atg36 contacts the Pex3 peroxisomal receptor, the fission machinery (Dnm1, Vps1), and the autophagosomal adaptor Atg11.
A more practical approach, i.e., a transient expression assay skipping the revertant selection by P12/UV, (39) was also developed for further isolation of PEX cDNAs including nine others, PEX1, PEX3, PEX5, PEX6, PEX12, PEX13, PEX14, PEX19, and PEX26 (21), (34), (40)-(48) (Table 3; Fig.
An alternative strategy, i.e., the homology search by screening the expressed sequence tag database using yeast PEX genes, successfully made it feasible to isolate human orthologue genes responsible for PBDs: (22), (24), (34) PEX1, (55), (56) PEX3, (57) PEX5, (58) PEX6, (59) PEX7, (60)-(62) PEX10, (63),(64) PEX12, (65) PEX13, (66) PEX14, (67) and PEX16.
Defects of PEX3, PEX16 and PEX19 encoding membrane-assembly peroxins lead to absence of ghosts and cause ZS phenotypes.
Three mammalian peroxins, Pex3p, Pex16p, and Pex19p, exclusively required for peroxisomal membrane assembly were isolated by the functional phenotype-complementation assay on pex3 and pex19 CHO cell mutants (41), (47) and the EST database search using yeast PEX genes.
The Panama Canal expansion has been good for us so far, and we now have a direct Asian service with PEX3 and we're seeing more Asian cargo as a result.