PEX3

PEX3

A gene on chromosome 6q24.2 that encodes a peroxin, an integral membrane protein involved in peroxisome biosynthesis and integrity, which assembles membrane vesicles before translocation of matrix proteins.
 
Molecular pathology
PEX3 mutations are associated with a variant of  Zellweger syndrome.
References in periodicals archive ?
The Panama Canal expansion has been good for us so far, and we now have a direct Asian service with PEX3 and we're seeing more Asian cargo as a result.
CMA CGM has called at the Port of New Orleans since 2009 and currently operates three weekly services, the Med-Americas Service to the Caribbean and South and Central American ports from New Orleans, the Victory Bridge Service to Northern European ports and the PEX3 service, a direct weekly service to Asia.
a transient expression assay skipping the revertant selection by P12/UV, (39) was also developed for further isolation of PEX cDNAs including nine others, PEX1, PEX3, PEX5, PEX6, PEX12, PEX13, PEX14, PEX19, and PEX26 (21), (34), (40)-(48) (Table 3; Fig.
the homology search by screening the expressed sequence tag database using yeast PEX genes, successfully made it feasible to isolate human orthologue genes responsible for PBDs: (22), (24), (34) PEX1, (55), (56) PEX3, (57) PEX5, (58) PEX6, (59) PEX7, (60)-(62) PEX10, (63),(64) PEX12, (65) PEX13, (66) PEX14, (67) and PEX16.
Defects of PEX3, PEX16 and PEX19 encoding membrane-assembly peroxins lead to absence of ghosts and cause ZS phenotypes.
2000) PEX3 is the causal gene responsible for peroxisome membrane assembly-defective Zellweger syndrome of complementation group G.
2004) PEX3 functions as a PEX19 docking factor in the import of class I peroxisomal membrane proteins.
2012) The role of conserved PEX3 regions in PEX19 binding and peroxisome biogenesis.
2014) PEX16 contributes to peroxisome maintenance by constantly trafficking PEX3 via the ER.
2016) Human peroxin PEX3 is cotranslationally integrated into the ER and exits the ER in budding vesicles.
2014) The membrane peroxin PEX3 induces peroxisome-ubiquitination-linked pexophagy.