PEX2

PEX2

A gene on chromosome 8q21.1 that encodes a peroxin, an integral membrane protein involved in peroxisome biosynthesis and integrity, which assembles membrane vesicles before translocation of matrix proteins.

Molecular pathology
Defects of PEX2 cause peroxisome biogenesis disorder complementation group 5, Zelleger syndrome and a form of Refsum disease.
References in periodicals archive ?
An E3 ubiquitin ligase responsible for Pex5 ubiquitination has been recently found with Pex2 at least upon nutrient starvation conditions [194].
Shatseva et al., "PEX2 is the E3 ubiquitin ligase required for pexophagy during starvation," The Journal of Cell Biology, vol.
Pex5 is additionally targeted by ubiquitination via the starvation-inducible Pex2. Modified Pex5 interacts with the autophagosomal adaptors NBR1 and p62.
(2009) Pex2 and Pex12 function as proteinubiquitin ligases in peroxisomal protein import.
(1997) Targeted deletion of the PEX2 peroxisome assembly gene in mice provides a model for Zellweger syndrome, a human neuronal migration disorder.