PEX19

PEX19

A gene on chromosome 1q23.2 that encodes a peroxin involved in early peroxisomal biogenesis, which acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins.
  
Molecular pathology
PEX19 mutations cause peroxisome biogenesis spectrum disorder, complementation type 14 and a clinical form of Zellweger syndrome.
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References in periodicals archive ?
Human PEX5, (49),(50) PEX14, (51) and PEX19 (PXF) (52) were earlier identified.
Defects of PEX3, PEX16 and PEX19 encoding membrane-assembly peroxins lead to absence of ghosts and cause ZS phenotypes.
2000) PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis.
2004) PEX3 functions as a PEX19 docking factor in the import of class I peroxisomal membrane proteins.
2012) The role of conserved PEX3 regions in PEX19 binding and peroxisome biogenesis.