PEX14

PEX14

A gene on chromosome 1p36.22 that encodes peroxin-14, a peroxisomal membrane protein that is an integral part of the peroxisomal import machinery, acting as a transcriptional co-repressor and interacting with a histone deacetylase. 

Molecular pathology
PEX14 mutations cause peroxisome biogenesis spectrum disorders—e.g., Zellweger syndrome.
References in periodicals archive ?
a transient expression assay skipping the revertant selection by P12/UV, (39) was also developed for further isolation of PEX cDNAs including nine others, PEX1, PEX3, PEX5, PEX6, PEX12, PEX13, PEX14, PEX19, and PEX26 (21), (34), (40)-(48) (Table 3; Fig.
the homology search by screening the expressed sequence tag database using yeast PEX genes, successfully made it feasible to isolate human orthologue genes responsible for PBDs: (22), (24), (34) PEX1, (55), (56) PEX3, (57) PEX5, (58) PEX6, (59) PEX7, (60)-(62) PEX10, (63),(64) PEX12, (65) PEX13, (66) PEX14, (67) and PEX16.
2004) Identification of a new complementation group of the peroxisome biogenesis disorders and PEX14 as the mutated gene.
III] specific 3-Hydroxy-3-methylglutaryl- HMGCS1 Acetyl-CoA coenzyme A synthase 1 metabolism Myristoylated alanine-rich MARCKS Actin binding, protein kinase C substrate cell motility Nedd4 family interacting NDFIP2 Signal transducer protein 2 activity Proteasome subunit, beta type, 1 PSMB1 Ubiquitin-dependent protein catabolism Peroxisomal biogenesis factor 14 PEX14 Integral to [MMA.