PEX13

PEX13

A gene on chromosome 2p16.1 that encodes peroxin-13, a peroxisomal membrane protein that binds type-1 peroxisomal-targeting signal receptor and is part of the peroxisomal translocation machinery.

Molecular pathology
PEX13 mutations cause peroxisome biogenesis spectrum disorders—e.g., Zellweger syndrome.
References in periodicals archive ?
A more practical approach, i.e., a transient expression assay skipping the revertant selection by P12/UV, (39) was also developed for further isolation of PEX cDNAs including nine others, PEX1, PEX3, PEX5, PEX6, PEX12, PEX13, PEX14, PEX19, and PEX26 (21), (34), (40)-(48) (Table 3; Fig.
An alternative strategy, i.e., the homology search by screening the expressed sequence tag database using yeast PEX genes, successfully made it feasible to isolate human orthologue genes responsible for PBDs: (22), (24), (34) PEX1, (55), (56) PEX3, (57) PEX5, (58) PEX6, (59) PEX7, (60)-(62) PEX10, (63),(64) PEX12, (65) PEX13, (66) PEX14, (67) and PEX16.
(2003) Pex13 inactivation in the mouse disrupts peroxisome biogenesis and leads to a Zellweger syndrome phenotype.