PEX13

PEX13

A gene on chromosome 2p16.1 that encodes peroxin-13, a peroxisomal membrane protein that binds type-1 peroxisomal-targeting signal receptor and is part of the peroxisomal translocation machinery.

Molecular pathology
PEX13 mutations cause peroxisome biogenesis spectrum disorders—e.g., Zellweger syndrome.
References in periodicals archive ?
a transient expression assay skipping the revertant selection by P12/UV, (39) was also developed for further isolation of PEX cDNAs including nine others, PEX1, PEX3, PEX5, PEX6, PEX12, PEX13, PEX14, PEX19, and PEX26 (21), (34), (40)-(48) (Table 3; Fig.
the homology search by screening the expressed sequence tag database using yeast PEX genes, successfully made it feasible to isolate human orthologue genes responsible for PBDs: (22), (24), (34) PEX1, (55), (56) PEX3, (57) PEX5, (58) PEX6, (59) PEX7, (60)-(62) PEX10, (63),(64) PEX12, (65) PEX13, (66) PEX14, (67) and PEX16.
Complementation groups (CGs) and PEX genes of peroxisome deficiencies Gene CG PBD CHO mutants US/EU Japan PEX1 1 E ZS, NALD *, IRD * Z24, ZP107 PEX2 10 F ZS, IRD * Z65 PEX3 12 G ZS ZPG208 PEX5 2 ZS, NALD ZP105 *, ZP139 PEX6 4(6) C ZS, NALD * ZP92 PEX7 11 R RCDP ZPG207 PEX10 7(5) B ZS, NALD PEX11[beta] 16 ZS PEX12 3 ZS, NALD, IRD ZP109 PEX13 13 H ZS, NALD * ZP128 PEX14 15 K ZS ZP110 PEX16 9 D ZS PEX19 14 J ZS ZP119 PEX26 8 A ZS, NALD *, IRD * ZP124, ZP167 ZP114 Gene Ps-memb.