SLC25A4

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SLC25A4

A gene on chromosome 4q35 that encodes a mitochondrial solute carrier protein, which functions as a gated pore that translocates ADP from the mitochondrial matrix into the cytoplasm. SLC25A4 forms a homodimer embedded in the inner mitochondria membrane.

Molecular pathology
SLC25A4 mutations cause autosomal dominant progressive external ophthalmoplegia and familial hypertrophic cardiomyopathy.
References in periodicals archive ?
applicants must submit an offer for the following mandatory additional services: - peo1: operation of secondary ecs networks and loopback outside technical premises for sites 1, 2 and 3, - peo2: supply and management of electricity in the form of an mfi market (flat rate contract with profit-sharing) and operation of electrical installations with guaranteed energy performance for all sites.
[rho] (a) MFI (b) [[eta].sub.0(190[degrees]C)] (c) (g/[cm.sup.3]) (dg/min) (Pa.s) PPI 0.900 38 620 PP2 0.900 11 3000 PEO1 0.955 30 270 PEO2 0.870 5.0 1800 PEO3 0.870 1.0 12000 [M.sub.w] [M.sub.w]/[M.sub.n] (kg/mol) (-) PPI 180 3.8 PP2 270 5.8 PEO1 60 3.6 PEO2 80 1.8 PEO3 120 2.0 (a) At 25[degrees]C, ASTM D 792.
The molecular weights of PEQ were determined in DMF at 25[degrees]C on a Viskotek Triple Detector GPC (Shimadzu Chromatograph and Viskotek T60A Dual Detector) using a PEO standard of Mn = 217,800 and PD = 1.02: Mn = 103,600, PD (polydispersity) = 4.51 for PEO1 and Mn = 172,700, PD = 2.58 for PEO2. Na-MMT was from University of Missouri-Columbia, Source Clay Minerals Repository (USA) and B34 (bentonite with dimethylditallow ammonium cations) was from Rheox (USA).
The onset of melting of the neat PEO2 from the DSC curve is about 60.4[degrees]C, the peak temperature 66.6[degrees]C and the crystallinity of PEQ 90 [+ or -] 2%, using [DELTA][H.sub.m.sup.o] = 197 J/g of 100% crystalline PEO.
PEO of different molecular weights (PEO1 or PEO2) were used to investigate the effects of polymer MW on final hybrids and the kinetics of melt intercalation.
Figure 7 shows the fraction of PEO intercalated hybrid as a function of time at 85[degrees]C for PEO1 or PEO2 in the PEO/MMT system.
Comparing these two series of kinetic data, PEO with low MW (PEO1) goes into MMT more rapidly than that of PEO2 with higher MW.
The effective diffusion rate (D/[a.sup.2]) calculated from the best fit line for PEOl and PEO2 is 3.54 X [10.sup.-5] and 2.72 x [10.sup.-5] [sec.sup.-1], respectively, for the melt intercalation at 85[degrees]C.
Material [M.sub.w] [M.sub.w]/[M.sub.n] mol-% comonomer PE04 238,000 3.5 -- PEH4 [c] 160,300 3.0 1.78 (1-hexene) PEO2 [c] 103,800 3.5 1.83 (1-octene) F1 [b] 105,000 3.0 5.95 (1-octene) Material [Short.sup.*] Chain Branching PE04 0.0 PEH4 [c] 8.6 PEO2 [c] 8.7 F1 [b] 32 (a.)Branching given as [CH.sub.3]/1000C.