PELD score

PELD score

[Acronym for pediatric end-stage liver disease]
A tool for characterizing the severity of liver disease in pediatric patients (under 12 ), used to determine their priority for receipt of donor organs. Patients with higher scores (more severe disease) are given a higher priority for transplantation. The score is based on repeated measurements of five variables: the patient's age, serum albumin level, serum bilirubin level, INR (international normalized ratio), and growth failure, entered into the following equation: PELD score = 0.436 (if patient is listed before age 1 year) — 0.687Ln(serum albumin) + 0.480LN(serum bilirubin) +1.857LN(INR) +0.667(for growth failure that is more than 2 standard deviations below normal).
References in periodicals archive ?
"With use of the PELD score, the ranking of risk among children was preserved, but direct comparisons between adult and pediatric candidates were not accurate," the authors write.
The researchers found that there was concordance between PELD scores and mortality among the full cohort (C statistic, 0.8387) and the reduced cohort (C statistic, 0.8123).
The PELD score estimates severity of the liver disease and approximates the likely survival for patients who are waiting for a transplant.
(v) Awareness about HPS in the pediatric population may increase patients' PELD scores that can improve the likelihood that they will be transplanted and improve patient survival.
The PELD score, derived from bilirubin, albumin, INR, growth failure and patient age when first placed on the waiting list, may be calculated with a tool available on the United Network for Organ Sharing (UNOS) website.
The PELD score has not been proven to be a successful predictor of post-transplantation outcome, but has also not been shown to adversely affect results.
OPTN policy prioritizes liver candidates local to the organ donor with a MELD or PELD score of 15 or higher, than those candidates within the region of the donor who have scores 15 or higher, before any less urgent candidates may be considered.
The higher the MELD or PELD score, the greater the risk of dying from liver disease.
She was classified as Child-Pugh C (score of 10) with a PELD score of 29, rapidly progressing to refractory ascites.
There were significant differences in the age at transplantation, time between KPE and transplantation, and PELD scores between patients with BA who underwent KPE at our center and those patients from other institutes (p<0.05).
In February 2002, the MELD and PELD scores were implemented to better prioritize patients at higher risk of short-term mortality on the waiting list [69, 70].
MELD and PELD scores are considered more accurate than the Child-Pugh score in determining short-term mortality, (16) and are used by the United Network of Organ Sharing (UNOS) for liver allocation.