PEG-ADA


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adenosine

(a-den'o-sen?) [Ger. blend of adenine + ribose]
A nucleotide containing adenine and ribose.

adenosine 3',5'-cyclic monophosphate

Abbreviation: AMP
A cyclic form of adenosine. Its synthesis from adenosine triphosphate (ATP) is stimulated by an enzyme, adenylate cyclase (also called cyclic AMP synthetase). Adenosine 3',5'-cyclic monophosphate is important in a wide variety of metabolic responses to cell stimuli.

adenosine deaminase conjugated with polyethylene glycol

Abbreviation: PEG-ADA
A cytoplasmic enzyme used to treat severe combined immunodeficiency disease (SCID) due to adenosine deaminase deficiency. Trade name is Adagen.
See: severe combined immunodeficiency disease

adenosine diphosphate

Abbreviation: ADP
A compound of adenosine containing two phosphoric acid groups. ADP is used to synthesize ATP with the energy released in cell respiration. When ATP is used for cellular functions such as protein synthesis, ADP is reformed.

adenosine monophosphate

Abbreviation: AMP; 5'-AMP
A substance formed by condensation of adenosine and phosphoric acid. It is one of the hydrolytic products of nucleic acids and is present in muscle, red blood cells, yeast, and other nuclear material.
Synonym: adenylic acid

adenosine triphosphatase

Abbreviation: ATPase
An enzyme that splits adenosine triphosphate to yield phosphate and energy.

adenosine triphosphate

Abbreviation: ATP
A compound of adenosine containing three phosphoric acid groups. Its chemical formula is C10H16N5O13P3. ATP is present in all cells and is formed when energy is released from food molecules during cell respiration. Cells contain enzymes to hydrolyze ATP into ADP, phosphate, and energy, which is then available for cellular functions such as mitosis.

adenosine deaminase conjugated with polyethylene glycol

Abbreviation: PEG-ADA
A cytoplasmic enzyme used to treat severe combined immunodeficiency disease (SCID) due to adenosine deaminase deficiency. Trade name is Adagen.
See: severe combined immunodeficiency disease
See also: adenosine
Medical Dictionary, © 2009 Farlex and Partners

PEG-ADA

An orphan drug that is useful in treating SCID related to ADA deficiency.
Mentioned in: Severe Combined Immunodeficiency
Gale Encyclopedia of Medicine. Copyright 2008 The Gale Group, Inc. All rights reserved.
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References in periodicals archive ?
Pegademase bovine (PEG-ADA) for the treatment of infants and children with severe combined immunodeficiency (SCID).
Adenosin deaminasa en el sindrome de inmunodeficiencia combinada severa
During enzyme replacement therapy with PEG-ADA, ADA activity ranged from undetectable to 14 555 nmol x [s.sup.-1] x [(L plasma).sup.-1].
Except in those few cases where bone marrow from an HLA/MLR-compatible sibling donor has been available, therapy for ADA deficiency has been based on enzyme replacement with PEG-modified ADA and, since 1990, on gene therapy transfer, the latter requiring concomitant PEG-ADA therapy until recently (24).
Capillary electrophoresis in diagnosis and monitoring of adenosine deaminase deficiency

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