PEG-ADA

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adenosine

(a-den'o-sen?) [Ger. blend of adenine + ribose]

A nucleotide containing adenine and ribose.

adenosine 3',5'-cyclic monophosphate

Abbreviation: AMP

A cyclic form of adenosine. Its synthesis from adenosine triphosphate (ATP) is stimulated by an enzyme, adenylate cyclase (also called cyclic AMP synthetase). Adenosine 3',5'-cyclic monophosphate is important in a wide variety of metabolic responses to cell stimuli.

adenosine deaminase conjugated with polyethylene glycol

Abbreviation: PEG-ADA

A cytoplasmic enzyme used to treat severe combined immunodeficiency disease (SCID) due to adenosine deaminase deficiency. Trade name is Adagen.

See: severe combined immunodeficiency disease

adenosine diphosphate

Abbreviation: ADP

A compound of adenosine containing two phosphoric acid groups. ADP is used to synthesize ATP with the energy released in cell respiration. When ATP is used for cellular functions such as protein synthesis, ADP is reformed.

adenosine monophosphate

Abbreviation: AMP; 5'-AMP

A substance formed by condensation of adenosine and phosphoric acid. It is one of the hydrolytic products of nucleic acids and is present in muscle, red blood cells, yeast, and other nuclear material.

Synonym: adenylic acid

adenosine triphosphatase

Abbreviation: ATPase

An enzyme that splits adenosine triphosphate to yield phosphate and energy.

adenosine triphosphate

Abbreviation: ATP

A compound of adenosine containing three phosphoric acid groups. Its chemical formula is C₁₀H₁₆N₅O₁₃P₃. ATP is present in all cells and is formed when energy is released from food molecules during cell respiration. Cells contain enzymes to hydrolyze ATP into ADP, phosphate, and energy, which is then available for cellular functions such as mitosis.

adenosine deaminase conjugated with polyethylene glycol

Abbreviation: PEG-ADA

A cytoplasmic enzyme used to treat severe combined immunodeficiency disease (SCID) due to adenosine deaminase deficiency. Trade name is Adagen.

See: severe combined immunodeficiency disease

PEG-ADA

An orphan drug that is useful in treating SCID related to ADA deficiency.

Mentioned in: Severe Combined Immunodeficiency

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References in periodicals archive ?

Sin embargo; en los diez anos que se ha utilizado, la PEG-ADA ha probado ser efectiva para revocar el panorama clinico lamentable asociado con el SCID-ADA.

Adenosin deaminasa en el sindrome de inmunodeficiencia combinada severa

Nuestros datos demuestran que la terapia de reemplazo con PEG-ADA puede reducir la expresion de CXCR2, sugiriendo que la hipoxia media este efecto, puesto que el numero de celulas inflamatorias pulmonares no esta alterado despues del tratamiento (12).

Angiogenesis pulmonar mediada por adenosina via CXCL1/CXCR2

During enzyme replacement therapy with PEG-ADA, ADA activity ranged from undetectable to 14 555 nmol x [s.

Capillary electrophoresis in diagnosis and monitoring of adenosine deaminase deficiency