PEComa

PEComa

A group of mesenchymal tumors composed of epithelioid and spindle cells displaying perivascular epithelioid (PEC) differentiation. The PEComa family of tumors includes angiomyolipoma, clear-cell "sugar" tumor of lung and gastrointestinal tract and other sites, lymphangioleimyomatosis, clear-cell myomelanocytic tumor of the falciform ligament.

PEComa

A rare, possibly mesenchymal tumour of unknown origin and of uncertain malignant potential, which can arise anywhere in the body and more commonly affects females.
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From a molecular genetic perspective, the recurrent chromosomal alterations in both renal and extrarenal tumors further support the concept of PEComa as a distinctive tumor entity, regardless of anatomic location.
The World Health Organization (WHO) defines PEComa as a "mesenchymal tumor that contains perivascular epithelioid cells presenting histological and immunohistochemical differences".
Angiomyolipoma (AML) has undergone a remarkable transformation in recent years, from a rare and rather pedestrian tumor type restricted to kidney, to a biologically fascinating and morphologically heterogenous entity which can occur in a wide variety of sites and which has been given the collective name of PEComa (5).
4) The smooth muscle component is derived from the perivascular epithelioid cell (PEC), and hence, AML is one of a number of tumors classified under the general term PEComa, a group that includes clear cell tumor and lymphangioleiomyomatosis.
Primary PEComa of the bladder treated with primary excision and adjuvant interferon-alpha immunotherapy: a case report.
They appeared to be emanating from the wall of the blood vessels, characteristic of the PEComa family of tumors (Figure 2).
In this case, a broad differential diagnosis of carcinoma, endometrial stromal tumour and PEComa were made histopathologically.
IHC positivity is 100% in PEComa cases for atleast one melanocytic marker, and 100 % positivity for smooth muscle actin in EL cases.
Archimedes simplifies software installation so that KPN's employees will have access to up-to-date, robust applications more quickly than they do now," said Jan Veldsink, business consultant for Pecoma Informatica, the Netherlands-based IT company that developed Archimedes.
Thereafter, neoplasms with an epithelioid cytomorphology and coexpression of smooth muscle and melanocytic immunomarkers have been increasingly reported under the designation of PEComa in a wide variety of anatomic locations.
The company also sold to LaBouchere, a Dutch bank; Modderkolk, an electrical engineering firm, and Pecoma, a Magic VAR who developed a subscriber management system for publisher Wolters Kluwer.