ETV4

(redirected from PEA3)
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ETV4

A gene on 17q21 that encodes a transcription activator that binds to the adenovirus E1A gene enhancer, specifically at the core-binding sequence 5'[AC]GGA[AT]GT-3'.
References in periodicals archive ?
4-kb MMP-1 promoter, they found PEA3 transcription factors acting as robust repressors, with binding sites at a "tandem" position (--3838 and--3824 relative to transcriptional start site).
The Ets protein PEA3 suppresses HER-2/neu overexpression and inhibits tumorigenesis.
Gene therapy [73] PEA3 DNA-binding protein Preclinical PEA3, which is encoded by a previously isolated gene of the ets family, has been used to target and downregulate a DNA sequence on the HER2 promoter leading to preferential inhibition of cell growth and tumour development of HER2- overexpressing cancer cells.