PDGFRA


Also found in: Acronyms.

PDGFRA

A gene on chromosome 4q12 that encodes a tyrosine-protein kinase which acts as a cell surface receptor for PDGFA, PDGFB and PDGFC, playing a key role in regulating embryonic development, survival and chemotaxis and, depending on context, up- or downregulates cell proliferation and migration.
References in periodicals archive ?
Avapritinib is an orally available, potent and highly selective inhibitor of KIT and PDGFRA. Previously published preclinical results have shown that avapritinib has potent activity against KIT and PDGFRA mutant kinases associated with GIST.
PDGFRA amplification is common in pediatric and adult high-grade astrocytomas and identifies a poor prognostic group in IDH1 mutant glioblastoma.
This is the reason why c-kit and PDGFRA mutations are mutually exclusive.
In case of CD-117 negativity, the tumours require further testing with C-KIT mutations and PDGFRA mutations.
Primer sequences used for real-time PCR analysis Gene primers sequence F: 5'-CGCAGCGAGCACCTCAAATCTAA-3' Olig2 R: 5'- CCCAGGGATGATCTAAGCTCTCGAA-3' F: 5'- GTG GGA CAT TCA TTG CGG A-3' PDGFRa Rev: 5' AAG CTG GCA GAG GAT TAG G-3' F: 5'- CCGACAGCAGGTCCATGTG-3' GFAP Rev: 5'-GTTGCTGGACGCCATTGC-3' F: 5'- GAAATCCCATCACCATCTTCCAGG-3' GAPDH Rev: 5'-GAGCCCCAGCCTTCTCCATG-3'
Olson, "PDGFRa controls the balance of stromal and adipogenic cells during adipose tissue organogenesis," Development, vol.
Imatinib is a selective inhibitor of tyrosine kinases, specifically KIT, PDGFRA, and ABL kinases.
Sundram, "Silent mutations in KIT and PDGFRA and coexpression of receptors with SCF and PDGFA in Merkel cell carcinoma: implications for tyrosine kinase-based tumorigenesis," Modern Pathology, vol.
Gotlib et al., "A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome," New England Journal of Medicine, vol.
We excluded 10 reports because they failed to report immunohistochemical (IHC) staining for CD117 or failed to report the results of the analysis discovered on GIST-1 (DOG-1) or platelet-derived growth factor receptor alpha (PDGFRA) markers for the CD117-negative tumors.
Zhang et al., "MiR-146a enhances angiogenic activity of endothelial cells in hepatocellular carcinoma by promoting PDGFRA expression," Carcinogenesis, vol.
The genotype distribution comparison of 42 SNPs among 96 Slovenian healthy controls (SLO) and a European population (data for 503 individuals were obtained from the Ensembl database) revealed significant differences (P < 0.05) in distribution of genotypes in 10 SNPs: rs3024498 (IL10), rs315952 (IL1RN), rs2256965 (LST1), rs2256974 (LST1), rs909253 (LTA), rs2857602 (LTA), rs3138045 (NFKB1A), rs3138056 (NFKB1A), rs7656613 (PDGFRA), and rs1891467 (TGFB2) (see Figures 1 and 2).