PDGFRA

(redirected from PDGFR-alpha)

PDGFRA

A gene on chromosome 4q12 that encodes a tyrosine-protein kinase which acts as a cell surface receptor for PDGFA, PDGFB and PDGFC, playing a key role in regulating embryonic development, survival and chemotaxis and, depending on context, up- or downregulates cell proliferation and migration.
References in periodicals archive ?
BLU-285 is a potent and selective inhibitor of KIT Exon 17 and PDGFR-alpha D842V mutants, which are key disease drivers of metastatic and treatment-resistant GIST.
Once the MTD or recommended dose has been established, patients with treatment-resistant GIST and PDGFR-alpha D842V mutant GIST will be enrolled in expansion cohorts.
The investigators are conducting exploratory laboratory analyses of tumor samples to determine whether mutations in KIT and PDGFR-alpha that present before starting treatment correlate with response.
We can already see this by the example of Gleevec, which is effective against cancers involving BCR-ABL mutations, KIT mutations, PDGFR-alpha mutations.
Glioblastoma multiforme is characterized by high incidence of PDGFR-alpha expression and susceptibility to the PDGFR-alpha-specific antibody MEDI-575 in mouse tumor models - presented by Dr.
Inhibition of PDGFR-alpha in tumor stroma with MEDI-575 enhances activity of carboplatin/ paclitaxel and delays tumor regrowth in a NSCLC xenograft model - presented by Dr.