PDGFRA

(redirected from PDGFR-alpha)

PDGFRA

A gene on chromosome 4q12 that encodes a tyrosine-protein kinase which acts as a cell surface receptor for PDGFA, PDGFB and PDGFC, playing a key role in regulating embryonic development, survival and chemotaxis and, depending on context, up- or downregulates cell proliferation and migration.
References in periodicals archive ?
The investigators are conducting exploratory laboratory analyses of tumor samples to determine whether mutations in KIT and PDGFR-alpha that present before starting treatment correlate with response.
We can already see this by the example of Gleevec, which is effective against cancers involving BCR-ABL mutations, KIT mutations, PDGFR-alpha mutations.