PDGFRA

(redirected from PDGFR-alpha)

PDGFRA

A gene on chromosome 4q12 that encodes a tyrosine-protein kinase which acts as a cell surface receptor for PDGFA, PDGFB and PDGFC, playing a key role in regulating embryonic development, survival and chemotaxis and, depending on context, up- or downregulates cell proliferation and migration.
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References in periodicals archive ?
Murry, "Progenitor cells identified by PDGFR-alpha expression in the developing and diseased human heart," Stem Cells and Development, vol.
Immunohistochemical examinations demonstrated that the carcinoma cell was positive for vimentin, AE1/AE3 (focal), CAM5.2 (focal), CK7 (focal), and CK19 (focal) but negative for EMA, S-100, SMA, desmin, H-caldesmon, DOG-1, HepPar-1, glypican-3, CD34, CD117, PDGFR-Alpha, CK20, bile stain, iron, and mucicarmine.
The inhibitory concentration ([IC.sub.50]) of sunitinib is 143 for PDGFR-alpha, 75 for PDGFR-beta, 21 and 34 for VEGFR 1 and VEGFR 2, respectively [5], which is higher than [IC.sub.50] for other tyrosine kinase inhibitors, making sunitinib one of the most potent inhibitors of VEGFR and PDGFR.
The investigators are conducting exploratory laboratory analyses of tumor samples to determine whether mutations in KIT and PDGFR-alpha that present before starting treatment correlate with response.
Morikawa et al., "Isolation of mouse mesenchymal stem cells on the basis of expression of Sca-1 and PDGFR-alpha," Nature Protocols, vol.