PDGFR

Also found in: Acronyms.

PDGFRB

A gene on chromosome 5q33.1 that encodes a tyrosine-protein kinase which acts as a cell surface receptor for homodimeric PDGFB and PDGFD and for PDGFA and PDGFB heterodimers, playing a key role in regulating embryonic development; cell proliferation, survival, differentiation, chemotaxis and migration; blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells; and migration of vascular smooth muscle cells and formation of neointima at sites of vascular injury sites. It is required for normal development of the cardiovascular system, for recruitment of mesangial cells and for development of the capillary network in the glomeruli.

PDGFR

PLATELET-DERIVED GROWTH FACTOR receptor.

Mentioned in ?

Gleevec

References in periodicals archive ?

The most common primary mutations are in KIT kinase, representing approximately 75% to 80% of cases, or in PDGFR kinase, representing approximately 5% to 10% of cases.

Deciphera Pharmaceuticals Reports Positive Updated Phase 1 Data for Ripretinib in Gastrointestinal Stromal Tumors

Ripretinib is an investigational KIT and PDGFR? kinase switch control inhibitor in clinical development for the treatment of KIT and/or PDGFR?-driven cancers, including gastrointestinal stromal tumors, or GIST, systemic mastocytosis, or SM, and other cancers.

Deciphera Pharmaceuticals Reports Positive Updated Phase 1 Data for Ripretinib in Gastrointestinal Stromal Tumors

Sunitinib malate is a small molecule kinase inhibitor with activity against a number of tyrosine kinase receptors, including VEGFR, PDGFR, KIT, RET, and FMS-like tyrosine kinase-3 (FLT3) [105].

Management Options for Advanced Low or Intermediate Grade Gastroenteropancreatic Neuroendocrine Tumors: Review of Recent Literature

Because CM082 plays a role in inhibiting PDGF signaling, we conjecture that CNV regression is a result of PDGFR inhibition and pericyte dysfunction.

The Effect of CM082, an Oral Tyrosine Kinase Inhibitor, on Experimental Choroidal Neovascularization in Rats

In the dog in this report, the expression of VEGFr, PDGFr, EGFr, and SCF was demonstrated by immunohistochemistry.

Injection-Site Sarcoma in a Dog: Clinical and Pathological Findings

Masson's trichrome; PCNA, proliferating cell nuclear antigen; PDGFR, platelet-derived growth factor receptor; ROS, reactive oxygen species; SR, sirius red; TGF-15, transforming growth factor-12; TNF-[alpha], tumor necrosis factor-[alpha]; UUO, unilateral ureteral obstruction.

Elsholtzia ciliata (Thunb.) Hylander attenuates renal inflammation and interstitial fibrosis via regulation of TGF-[beta] and Smad3 expression on unilateral ureteral obstruction rat model

Adult reproductive functions after early postnatal inhibition by imatinib of the two receptor tyrosine kinases, c-kit and PDGFR, in the rat testis.

The effects of imatinib mesylate on cellular viability, platelet derived growth factor and stem cell factor in mouse testicular normal leydig cells

In previous studies of glioma [24], squamous cell carcinoma of the head and neck [25], colorectal cancer [26], pancreatic cancer [27], and T cell lymphoma [28], PDGFR activation induced the intracellular signaling pathway and promoted cell migration, invasion, survival, and proliferation [29].

Expression of CAF-related proteins is associated with histologic grade of breast phyllodes tumor

La senalizacion aberrante de PDGFR induce la transformacion de pericitos a miofibroblastos, se puede presentar en consecuencia a los efectos del factor de crecimiento de hepatocitos y de TGF-[beta] ya que favorecen la sobreproduccion de PDGF en las celulas del epitelio tubular.

TGF-[beta] y otras moleculas profibroticas en enfermedad renal cronica

Pleuro-pulmonary solitary fibrous tumors: A clinicopathologic, immunohistochemical, and molecular study of 88 cases confirming the prognostic value of de Perrot staging system and p53 expression, and evaluating the role of c-kit, BRAF, PDGFRs (alpha/beta), c-met, and EGFR.

A case of solitary fibrous tumor arising from the palatine tonsil

To investigate which RTK signaling pathways participate in the proliferation of RO82-W-1 cells, we tested the activity of selective RTK inhibitors [42-46] targeting VEGFR (sorafenib), FGFR (PD166866 and PD173074), KIT (imatinib), and PDGFR (Ki6783) against 5 DTC cell lines including RO82-W-1 (Table 2), because lenvatinib inhibited these RTKs at [IC.sub.50] values of less than 100 nM (Supplementary Table S1) and RO82-W-1 cells express the mRNA of some of these RTKs (Supplementary Figure S5).

Antitumor activity of lenvatinib (E7080): an angiogenesis inhibitor that targets multiple receptor tyrosine kinases in preclinical human thyroid cancer models

Multikinase inhibitor 20% (1 year survival) [50] with activity against Raf, VEGF, PDGFR, Ret, and c-kit Sosa et al.

Anaplastic thyroid cancer: the addition of systemic chemotherapy to radiotherapy led to an observed improvement in survival--a single centre experience and the review of the literature