PDGFR


Also found in: Acronyms.

PDGFRB

A gene on chromosome 5q33.1 that encodes a tyrosine-protein kinase which acts as a cell surface receptor for homodimeric PDGFB and PDGFD and for PDGFA and PDGFB heterodimers, playing a key role in regulating embryonic development; cell proliferation, survival, differentiation, chemotaxis and migration; blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells; and migration of vascular smooth muscle cells and formation of neointima at sites of vascular injury sites. It is required for normal development of the cardiovascular system, for recruitment of mesangial cells and for development of the capillary network in the glomeruli.

PDGFR

PLATELET-DERIVED GROWTH FACTOR receptor.
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References in periodicals archive ?
The most common primary mutations are in KIT kinase, representing approximately 75% to 80% of cases, or in PDGFR kinase, representing approximately 5% to 10% of cases.
Ripretinib is an investigational KIT and PDGFR? kinase switch control inhibitor in clinical development for the treatment of KIT and/or PDGFR?-driven cancers, including gastrointestinal stromal tumors, or GIST, systemic mastocytosis, or SM, and other cancers.
Sunitinib malate is a small molecule kinase inhibitor with activity against a number of tyrosine kinase receptors, including VEGFR, PDGFR, KIT, RET, and FMS-like tyrosine kinase-3 (FLT3) [105].
Because CM082 plays a role in inhibiting PDGF signaling, we conjecture that CNV regression is a result of PDGFR inhibition and pericyte dysfunction.
In the dog in this report, the expression of VEGFr, PDGFr, EGFr, and SCF was demonstrated by immunohistochemistry.
Masson's trichrome; PCNA, proliferating cell nuclear antigen; PDGFR, platelet-derived growth factor receptor; ROS, reactive oxygen species; SR, sirius red; TGF-15, transforming growth factor-12; TNF-[alpha], tumor necrosis factor-[alpha]; UUO, unilateral ureteral obstruction.
Adult reproductive functions after early postnatal inhibition by imatinib of the two receptor tyrosine kinases, c-kit and PDGFR, in the rat testis.
In previous studies of glioma [24], squamous cell carcinoma of the head and neck [25], colorectal cancer [26], pancreatic cancer [27], and T cell lymphoma [28], PDGFR activation induced the intracellular signaling pathway and promoted cell migration, invasion, survival, and proliferation [29].
La senalizacion aberrante de PDGFR induce la transformacion de pericitos a miofibroblastos, se puede presentar en consecuencia a los efectos del factor de crecimiento de hepatocitos y de TGF-[beta] ya que favorecen la sobreproduccion de PDGF en las celulas del epitelio tubular.
Pleuro-pulmonary solitary fibrous tumors: A clinicopathologic, immunohistochemical, and molecular study of 88 cases confirming the prognostic value of de Perrot staging system and p53 expression, and evaluating the role of c-kit, BRAF, PDGFRs (alpha/beta), c-met, and EGFR.
To investigate which RTK signaling pathways participate in the proliferation of RO82-W-1 cells, we tested the activity of selective RTK inhibitors [42-46] targeting VEGFR (sorafenib), FGFR (PD166866 and PD173074), KIT (imatinib), and PDGFR (Ki6783) against 5 DTC cell lines including RO82-W-1 (Table 2), because lenvatinib inhibited these RTKs at [IC.sub.50] values of less than 100 nM (Supplementary Table S1) and RO82-W-1 cells express the mRNA of some of these RTKs (Supplementary Figure S5).