PDGFR


Also found in: Acronyms.

PDGFRB

A gene on chromosome 5q33.1 that encodes a tyrosine-protein kinase which acts as a cell surface receptor for homodimeric PDGFB and PDGFD and for PDGFA and PDGFB heterodimers, playing a key role in regulating embryonic development; cell proliferation, survival, differentiation, chemotaxis and migration; blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells; and migration of vascular smooth muscle cells and formation of neointima at sites of vascular injury sites. It is required for normal development of the cardiovascular system, for recruitment of mesangial cells and for development of the capillary network in the glomeruli.

PDGFR

PLATELET-DERIVED GROWTH FACTOR receptor.
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Abbreviations: DOG1, discovered on GIST-1; GIST, gastrointestinal stromal tumor; PDGFR, platelet-derived growth factor; SMA, smooth muscle actin; SFT, solitary fibrous tumor.
But the role of PDGFR signaling in the heart has been largely unexplored until now," said Dr.
Using special laboratory mice with limited cardiac PDGFR and mice with normal PDGFR signaling, researchers performed transverse aortic constriction (TAC)- a procedure widely used to study heart disease in which a band is placed at the aortic arch, resulting in acute pressure overload.
The preclinical research conducted by ARIAD scientists assessed the activity of ponatinib using cell lines expressing activated forms of FLT3, RET, KIT, PDGFR and FGFR1, each a kinase target associated with a specific tumor type.
Research conducted previously at MD Anderson Cancer Center shows significant cancer-killing synergy when Oncoprex is combined with erlotinib and a variety of other kinase inhibitors (TKIs) including EGFR, AKT, PDGFR, and Src targeted agents.
Telatinib is an oral small molecule drug that inhibits the VEGFR, PDGFR and KIT receptor tyrosine kinases.
Joint development of Regeneron's PDGFR Beta antibody as new candidate for potential combination therapy demonstrates both companies' strong commitment to ophthalmology
BAY 43-9006 also exerted an antiangiogenic effect by targeting the receptor tyrosine kinases VEGFR-2 and PDGFR and their associated signaling cascades.
Celgene Research Programs - c-fms, TYK2, PDGFR: Celgene announced for the first time progress on three Array-partnered research programs during their research and development event on April 8, 2010: c-fms (oncology), TYK2 (inflammation) and PDGFR (inflammation).
Selected Kit and PDGFR InhibitorsAB Science's Masitinib
XV-615 has the potential to improve efficacy for treatment of wet AMD because it targets two synergistic pathways mediated by VEGFR and PDGFR.
Pleuro-pulmonary solitary fibrous tumors: A clinicopathologic, immunohistochemical, and molecular study of 88 cases confirming the prognostic value of de Perrot staging system and p53 expression, and evaluating the role of c-kit, BRAF, PDGFRs (alpha/beta), c-met, and EGFR.