PDGFR

Also found in: Acronyms.

PDGFRB

A gene on chromosome 5q33.1 that encodes a tyrosine-protein kinase which acts as a cell surface receptor for homodimeric PDGFB and PDGFD and for PDGFA and PDGFB heterodimers, playing a key role in regulating embryonic development; cell proliferation, survival, differentiation, chemotaxis and migration; blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells; and migration of vascular smooth muscle cells and formation of neointima at sites of vascular injury sites. It is required for normal development of the cardiovascular system, for recruitment of mesangial cells and for development of the capillary network in the glomeruli.

PDGFR

PLATELET-DERIVED GROWTH FACTOR receptor.

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Gleevec

References in periodicals archive ?

The cells produce the shortened form of the protein by recognizing and using a specific series of nucleotides in the messenger RNA that encodes the instructions to make the PDGFR alpha protein.

Stem cells police themselves to reduce scarring

Inhibition of tyrosine kinases PDGFR and C-Kit by imatinib mesylate interferes with postnatal testicular development in the rat.

The effects of imatinib mesylate on cellular viability, platelet derived growth factor and stem cell factor in mouse testicular normal leydig cells

Also, stromal expression of PDGFR was associated with shorter overall survival.

Expression of CAF-related proteins is associated with histologic grade of breast phyllodes tumor

Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR.

Papel de la via fosfatidilinositol 3 kinasa (PI3K/Akt) en humanos

The problem with targeting normal receptors such as EGFR and PDGFR, is that even though they are expressed at high levels in cancer cells, they are also expressed in some normal tissues.

Molecular biology of brain cancer

Therefore, we examined PDGFR and found that the PDGFRs were also upregulated, with increased CF in rat PMCs induced by HG stimulation [Figure 5].

Blocking Posttranslational Core Fucosylation Ameliorates Rat Peritoneal Mesothelial Cell Epithelial-Mesenchymal Transition

It is well known that both PDGFR and EGFR are involved in the pathogenesis of renal fibrosis.

Elsholtzia ciliata (Thunb.) Hylander attenuates renal inflammation and interstitial fibrosis via regulation of TGF-[beta] and Smad3 expression on unilateral ureteral obstruction rat model

Discovered at Eisai's Tsukuba Research Laboratories and developed in-house, Lenvima is an orally administered molecular targeted agent that selectively inhibits the activities of several different molecules including VEGFR, FGFR, RET, KIT and PDGFR.

Eisai Receives European Commission Approval of Anticancer Agent Lenvima for Treatment of Advanced Thyroid Cancer Refractory to Radioactive Iodine

Classification of mutations found in hematological malignancies Class I mutations (induce proliferation or inhibit apoptosis) FLT3-ITD, cKit, PDGFR, TEL-PDGFR, FGFR JAK2, JAK3, Bcr-Abl N-Ras, K-Ras p53, NF1 Class II mutations (inhibit differentiation or induce immortalization) Runx 1/AML1, PU1, C/EBP[alpha] MLL fusions, PML-RA[R.

The molecular basis of myeloid malignancies

The tumour cells were strong positive for c-kit (CD117), S-100 protein and glial fibrillary acidic protein (GFAP), but did not harbour mutations in the c-kit and PDGFR genes.

Gastrointestinal autonomic nerve tumour of jejunum presenting as a perfore mass

The substance STI571, which has been named imatinib, was found to act as a powerful selective inhibitor of tyrosine kinases (c-ABL, BCR-ABL), of PDGFR receptor (platelet derived growth factor receptor) and of c-kit receptor.

Perforated gastrointestinal stromal tumour of jejunum--a rare case of acute abdomen and review of literature

Dasatinib, another TKI, is a potent PDGFR inhibitor that causes fluid retention in up to 50% of patients.

Chakalaka-induced vasodilatation in patients with chronic myeloid leukaemia on tyrosine kinase inhibitors