PDGFD


Also found in: Acronyms.

PDGFD

A gene on chromosome 11q22.3 that encodes platelet-derived growth factor D, a growth factor which plays a key role in regulating embryonic development and in cell proliferation, migration, survival and chemotaxis. It is mitogenic for macrophages and mesenchymal cells, and plays an important role in wound healing and in angiogenesis.

Molecular pathology
PDGFD appears to play a role in mesangial proliferative glomerulonephritis.
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They focused on PDGFD, already known to be a key component of growth signaling pathways in other tissues but not in the brain, because it appeared to have the biggest effect on brain cell growth in a crude preliminary experiment.
When they exposed mouse radial glial cells to PDGFD, it caused the cells to increase their numbers more rapidly than nonnal.
By helping to drive growth of the human cortex, PDGFD might have played an evolutionary role in the huge increase in cortical size in the evolution of mammals leading to the emergence of humans, according to Kriegstein.