PDGFC


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PDGFC

A gene on chromosome 4q32 that encodes platelet-derived growth factor C, a growth factor which plays a key role in regulating embryonic development and in cell proliferation, migration, survival and chemotaxis. It is mitogenic for mesenchymal cells and required for normal skeleton formation during embryonic development, especially of the craniofacial skeleton; for normal development of the palate; and for normal skin morphogenesis. It plays an important role in wound healing and in angiogenesis.
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DiCorleto and colleagues at the University of Washington in Seattle showed that endothelial cells, which make up the interior surface of arteries and veins, produce a biological factor -- known as PDGFc -- that promotes the growth of smooth-muscle cells.
One reason, he explains, is that safflower oil -- a fat containing almost no omega-3 -- also suppressed PDGFc formation, although with only a tenth or twentieth the potency of fish oil.
And that, he notes, is where their research suggests PDGFc production might be affected.