PDGFA


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PDGFA

A gene on chromosome 7p22 that encodes platelet-derived growth factor alpha, which plays a key role in regulating embryonic development and in cell proliferation, migration, survival and chemotaxis. It is mitogenic for mesenchymal cells and required for normal lung alveolar septation during embryogenesis, normal GI tract, Leydig cell and oligodendrocyte development, as well as normal spermatogenesis and myelination in the spinal cord and cerebellum. It plays a key role in wound healing.
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Boonmars et al., "Overexpression of PDGFA and its receptor during carcinogenesis of Opisthorchis viverrini-associated cholangiocarcinoma," Parasitology International, vol.
Imatinib (Gleevec, Novartis Pharmaceuticals, NJ), which functions by inhibiting and blocking the function of KIT and PDGFA, may achieve an 80% response in KIT exon 11 mutation but only a 50% response in KIT exon 9 mutation.
Early myotome specification regulates PDGFA expression and axial skeleton development.
On the contrary, other genes did not display significant changes though they code for cytokines or growth factors with a chemoattractant role on different types of stem cells, such as Cxcl12/Sdf1, stem cell factor (SCF), Igf1, Hgf, Pdgfa, and Vegfa.
MSCs act as trophic mediators and some of the trophic factors found to be upregulated in ischemic WJ-MSCs were IGF1, VEGFA, and PDGFA (Table 2).