PDGFA


Also found in: Acronyms.

PDGFA

A gene on chromosome 7p22 that encodes platelet-derived growth factor alpha, which plays a key role in regulating embryonic development and in cell proliferation, migration, survival and chemotaxis. It is mitogenic for mesenchymal cells and required for normal lung alveolar septation during embryogenesis, normal GI tract, Leydig cell and oligodendrocyte development, as well as normal spermatogenesis and myelination in the spinal cord and cerebellum. It plays a key role in wound healing.
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Imatinib (Gleevec, Novartis Pharmaceuticals, NJ), which functions by inhibiting and blocking the function of KIT and PDGFA, may achieve an 80% response in KIT exon 11 mutation but only a 50% response in KIT exon 9 mutation.
Early myotome specification regulates PDGFA expression and axial skeleton development.
Presentation (#4144): High Expression of HIF1a is a strong predictor of clinical outcome in patients with pancreatic ductal adenocarcinomas and correlated to PDGFA, VEGF and bFGF