PDGFA

(redirected from PDGF-A)
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PDGFA

A gene on chromosome 7p22 that encodes platelet-derived growth factor alpha, which plays a key role in regulating embryonic development and in cell proliferation, migration, survival and chemotaxis. It is mitogenic for mesenchymal cells and required for normal lung alveolar septation during embryogenesis, normal GI tract, Leydig cell and oligodendrocyte development, as well as normal spermatogenesis and myelination in the spinal cord and cerebellum. It plays a key role in wound healing.
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Betsholtz, "Roles for PDGF-A and sonic hedgehog in development of mesenchymal components of the hair follicle," Development, vol.
Hall et al., "Defective oligodendrocyte development and severe hypomyelination in PDGF-A knockout mice," Development, vol.
It has been demonstrated that many cell types within the overgrown gingival tissues express PDGF-A, PDGF-B, and both PDGF-receptors and are in agreement with the fact that PDGF is produced by a variety of cell types [48, 49].