platelet-derived growth factor receptor

(redirected from PDGF receptor)

platelet-derived growth factor receptor

Any of a family of catalytic receptors with intracellular tyrosine kinase activity, which play key roles in regulating various biological processes such as embryonic development, angiogenesis, cell proliferation and differentiation. They also play a role in the pathogenesis of diseases, including cancer. Ligand binding to receptors triggers receptor dimerisation and transphosphorylation at specific tyrosine residues, activating intracellular kinase activity and initiating intracellular signalling through the MAPK, PI3K and PKC-gamma pathways.

PDGFRs are composed of three isoforms (a homodimer of PDGFRalpha, a homodimer of PDGFRbeta, and a heterodimer of PDGFRalpha and –beta) and four ligands (PDGF-A, -B, -C and -D).
References in periodicals archive ?
The company will use the proceeds from the contract for the development of an inhaled PDGF receptor kinase inhibitor to treat pulmonary arterial hypertension (PAH).
Adult animals lacking expression of the beta cell PDGF receptor were also less able than their peers to regenerate beta cells that were artificially damaged by a chemical compound, and they became severely diabetic after such treatment.
TAK-593 is a novel small molecule selective inhibitor of the tyrosine kinases for the VEGF and PDGF receptor families.
A recent report demonstrated that SSc patients have circulating antibodies directed against the PDGF receptor that are capable of triggering activation of fibroblasts.
Sorafenib is a multifunctional tyrosine kinase inhibitor with activity against Raf-1, VEGF receptor-2 and 3, PDGF receptor [beta], Flt-3 and c-kit.
The [alpha] form of the PDGF receptor in particular binds PDGF with high specificity, resulting in growth stimulation through interactions with the ras oncogene.
Inhibition of the PDGF receptor by red wine flavonoids provides a molecular explanation for the "French paradox".
are described for determining the level of expression of genes for specific types of PDGF receptor
On the other hand, significantly more PDGF receptor sites per cell are seen in leiomyomas than in the myometrium, although the PDGF receptor binding affinity in the tumor cells is lower than that of the myometrium (Fayed et al.
Proceeds from the contract will be used to develop an inhaled PDGF receptor kinase inhibitor for the treatment of pulmonary arterial hypertension (PAH).
XL820 inhibits the VEGF receptor, KIT and the PDGF receptor, which are clinically validated targets implicated in a variety of human cancers.
Induction of the lung myofibroblast PDGF receptor system by urban ambient particles from Mexico City.