17] Researchers are studying PDGF
for its use as an adjunct to regenerative therapy.
A number of studies suggest that PDGF
and bFGF are involved both in the initial wave of medial SMC proliferation as well as SMC migration to the intima (25, 26).
There is also interest in trials of small molecule kinase inhibitors including imatinib, an inhibitor of Bcr-Abl and of the PDGF
developed a colorimetric assay that uses gold nanoparticles (NPs) to measure PDGFs
and their receptors (16).
proteins, for example, by measuring mRNA in cells with PDGF
receptor type-specific DNA probes or by
When they blocked the expression of PDGF
receptors in laboratory mice, they found that young animals (2 to 3 weeks old) made less Ezh2 and had significantly fewer beta cells than control animals.
also causes replication of endothelial cells, causing budding of new capillaries (angiogenesis).
But in atherosclerosis, says Ross, PDGF
"turns normal response to injury into an exuberant response, resulting in the narrowing of the lumen of the artery.
All Augment([R]) branded products are based upon recombinant human platelet-derived growth factor (rhPDGF-BB), which is an engineered form of PDGF
, one of the body's principal agents to stimulate and direct healing and regeneration.
These factors, including VEGF and PDGF
, have shown to induce follicular growth and result in strengthening of miniaturized hairs in multi pattern hair loss as well as in other alopecia conditions.
Increased serum PDGF
concentrations during and after hemodialysis, attributable to PLT-membrane contact at artificial surfaces, may be directly involved in the increased frequency of atherosclerosis in hemodialysis patients (2).
IL-1, IL-6, and PDGF
mRNA expression in alveolar cells following stimulation with tobacco-derived antigen.