PDE9A

PDE9A

A gene on chromosome 21q22.3 that encodes a cyclic nucleotide phosphodiesterase, which hydrolyses cAMP to AMP and cGMP to GMP, thus playing a role in signal transduction.
References in periodicals archive ?
First, we designed real-time quantitative methylation-specific PCR (gMSP) assays (21) to target the unmethylated form of CGI084, which is linked to PDE9A (phosphodiesterase 9A), in the placenta (U-PDE9A) and the methylated form in maternal blood cells (M-PDE9A).
To test this hypothesis, we examined samples of maternal plasma obtained from 12 third-trimester pregnancies (8 male and 4 female fetuses) before and after delivery for the presence of the unmethylated form of CGI084 (U-PDE9A), which is linked to the PDE9A gene.
We designed a MassEXTEND assay to detect U-CGI137 after MSP that was based on only 5 identified differentially methylated CpG sites within CGI137, in contrast to 10 such sites in PDE9A (cf.