PDE8B | definition of PDE8B by Medical dictionary
PDE8B A gene on chromosome 5q13.3 that encodes a cAMP-specific cyclic nucleotide phosphodiesterase, which hydrolyses the second messenger cAMP to AMP and thus plays a role in regulating physiological processes.
PDE8B mutations are linked to autosomal dominant striatal degeneration.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive
Four phosphodiesterases (PDE4D, PDE7A, PDE7B, and PDE8B
) and two adenylate cyclases (ADCY2, ADCY4) were upregulated, and adenylate kinase (ADK) and AMP deaminase 3 (AMPD3) were downregulated in stimulated versus unstimulated cells.
The genotypes most affecting LDL-cholesterol concentrations were identified as LOC100289611, PKDCC, DCTD, LASS6, KDSR, UBXN6, PDE8B
, DMWD, SPATA20, and RGS7BP.
, located near SNP of ASGA0010696, is a major regulator of an adrenal steroidogenesis (Tsai et al., 2011) and modulates basal corticosterone synthesis (Tsai and Beavo, 2011).